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This study aimed to evaluate the effectiveness of computer\u2010assisted SSRO in reducing the incidence and severity of neurosensory alterations, using a surgical guide fabricated by computer\u2010aided design and rapid prototyping (to guide bone cutting lateral to the inferior alveolar nerve).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective double\u2010blind, randomized controlled, clinical trial of computer\u2010assisted SSRO vs conventional SSRO (assigned in a split\u2010mouth design) in eight patients, mean age 23 (range 18\u201330) years, who participated in one session preoperatively and three sessions at 1\u2009week and 1, 3 and 6\u2009months postoperatively. At each session, subjective oral sensation was scored and quantitative sensory tests were performed. Neurosensory changes were compared between the two sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that on the computer\u2010assisted SSRO sides, patients had lower postoperative abnormal thresholds for the Semmes\u2013Weinstein monofilaments on lower lip and chin (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05 at 3\u2009months) and for the two\u2010point discrimination on lower lip (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05 at 1\u2009week) and chin (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05 at 6\u2009months), with fewer abnormal self\u2010reported changes in lower lip sensation (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05 at 1\u2009week) after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings imply that computer\u2010assisted SSRO is associated with better levels of neurosensory function after surgery. 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