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Robotic\u2010assisted minimally invasive esophagectomy (RAMIE) with its virtual reality simulators offers a realistic three\u2010dimensional environment that facilitates dissection in the narrow working space, but it is expensive and requires longer operative time. Therefore, the aim of this meta\u2010analysis was to assess the safety and feasibility of RAMIE versus MIE in patients with esophageal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>PubMed, EMBASE, Cochrane library, and Chinese Biomedical Literature databases were systematically searched up to 21 September 2018 for case\u2010controlled studies that compared RAMIE with MIE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Eight case\u2010controlled studies involving 1862 patients (931 under RAMIE and 931 under MIE) were considered. No statistically significant difference between the two techniques was observed regarding R0 resection rate (OR\u00a0=\u00a01.1174, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.8647), conversion to open (OR\u00a0=\u00a00.7095, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.7519), 30\u2010day mortality rate (OR\u00a0=\u00a00.8341, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.7696), 90\u2010day mortality rate (OR\u00a0=\u00a00.3224, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.3329), in\u2010hospital mortality rate (OR\u00a0=\u00a00.3733, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.3895), postoperative complications, number of harvested lymph nodes (mean difference [MD]\u00a0=\u00a00.8216, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.2039), operation time (MD\u00a0=\u00a024.3655\u00a0min, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.2402), and length of stay in hospitals (LOS) (MD\u00a0=\u00a0\u22125.0228\u00a0day, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1342). The meta\u2010analysis showed that RAMIE was associated with a significantly fewer estimated blood loss (EBL) (MD\u00a0=\u00a0\u221233.2268\u00a0mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0075). And the vocal cord palsy rate was higher in the MIE group compared with RAMIE, and the difference was significant (OR\u00a0=\u00a00.5696, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0447).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis indicated that RAMIE and MIE display similar feasibility and safety when used in esophagectomy. However, randomized controlled studies with larger sample sizes are needed to evaluate the benefit and harm in patients with esophageal cancer undergoing RAMIE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rcs.1988","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T09:13:57Z","timestamp":1549703637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Robotic\u2010assisted minimally invasive esophagectomy versus the conventional minimally invasive one: A meta\u2010analysis and systematic review"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-3544","authenticated-orcid":false,"given":"Dacheng","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Gansu University of Traditional Chinese Medicine  Lanzhou China"},{"name":"Department of Thoracic Surgery, Gansu Province People's Hospital  Lanzhou 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