{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:40:15Z","timestamp":1773369615726,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Robotics Computer Surgery"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A robotic system for Magnetic Resonance guided Focussed Ultrasound (MRgFUS) therapy of tumours in the breast, bone, thyroid, and abdomen was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A special C\u2010shaped structure was designed to be attached to the table of conventional magnetic resonance imaging (MRI) systems carrying 4 computer\u2010controlled motion stages dedicated to positioning a 2.75\u00a0MHz spherically focussed transducer relative to a patient placed in the supine position. The developed system was evaluated for its MRI compatibility and heating abilities in agar\u2010based phantoms and freshly excised tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compatibility of the system with a clinical high\u2010field MRI scanner was demonstrated. FUS heating in the phantom was successfully monitored by magnetic resonance thermometry without any evidence of magnetically induced phenomena. Cigar\u2010shaped discrete lesions and well\u2010defined areas of overlapping lesions were inflicted in excised tissue by robotic movement along grid patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed MRgFUS robotic system was proven safe and efficient by <jats:italic>ex\u2010vivo<\/jats:italic> feasibility studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rcs.2364","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T22:08:10Z","timestamp":1641593290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Robotic system for top to bottom MRgFUS therapy of multiple cancer types"],"prefix":"10.1002","volume":"18","author":[{"given":"Anastasia","family":"Antoniou","sequence":"first","affiliation":[{"name":"Department of Electrical Engineering, Computer Engineering, and Informatics Cyprus University of Technology  Limassol 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