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The aim of this work is to introduce a novel approach for automated calculation of ontology\u2010based planning proposals in mandibular reconstruction and conduct a feasibility study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The presented approach is composed of an RDF(S) ontology, a 3D mandible template and a calculator\u2010optimiser algorithm to automatically calculate reconstruction proposals with fibula grafts. To validate the viability of the approach, a feasibility study was conducted on 164 simulated mandibular reconstructions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ontology defines 244 different reconstruction variants and 80 analyses for optimization. In 146 simulated cases, a proposal could be automatically calculated (average time 8.79\u00a0\u00b1\u00a04.03\u00a0s). The assessments of the proposals by three clinical experts indicate the viability of the approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to the modular separation between computational logic and domain knowledge, the developed concepts can be easily maintained, reused and adapted for other applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rcs.2545","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T10:16:04Z","timestamp":1688379364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Automated calculation of ontology\u2010based planning proposals: An application in reconstructive oral and maxillofacial surgery"],"prefix":"10.1002","volume":"19","author":[{"given":"Niclas","family":"Hagen","sequence":"first","affiliation":[{"name":"Institute of Medical Informatics Heidelberg University Hospital  Heidelberg 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