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These can be shaped by different technologies, while 3D printing offers remarkable chances in terms of flexibility, accuracy, cost\u2010saving and customizability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study aims to evaluate strengths and limitations of the three main strategies that imply additive manufacturing for the implementation of cranial prosthesis: (i) direct printing of PLA (polylactic acid) skullcaps, mould casting of poly(methyl methacrylate) (PMMA) prosthesis using (ii) silicone mould manufactured from a 3D printed master, (iii) 3Dprinted TPU (thermoplastic polyurethane) mould.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All solutions achieved good geometric accuracy and excellent mechanical resistance. 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