{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:22:54Z","timestamp":1785529374748,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Robotics Computer Surgery"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The value of the retroperitoneal (R\u2010RAPN) compared with the conventional transperitoneal (T\u2010RAPN) approach in robot\u2010assisted partial nephrectomy has not been finally clarified. The current work's objective was to prospectively investigate R\u2010RAPN versus T\u2010RAPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a prospective, controlled, non\u2010randomized study with a non\u2010inferiority design. The primary endpoint was Trifecta achievement. The sample size calculation required 141 T\u2010RAPN and 94 R\u2010RAPN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When the recruitment target of 141 was reached in the T\u2010RAPN arm, only 34 R\u2010RAPN had been performed, so the study was terminated early. Trifecta as the main outcome parameter was achieved in 82% of the R\u2010RAPN and 76% of the T\u2010RAPN groups, so no sign for inferiority could be detected (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this prospective study, there was no evidence of inferiority of R\u2010RAPN compared to T\u2010RAPN for the Trifecta endpoint. R\u2010RAPN may be an individually advantageous alternative to T\u2010RAPN for selected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The study was registered in the German Clinical Trials Register (DRKS00028619).<\/jats:p><\/jats:sec>","DOI":"10.1002\/rcs.70077","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:51:12Z","timestamp":1748325072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Retroperitoneal Versus Transperitoneal Robot Assisted Partial Nephrectomy: A Prospective Controlled Non\u2010Randomized Single Centre Study Non\u2010Inferiority Design"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1286-0502","authenticated-orcid":false,"given":"Rene","family":"Mager","sequence":"first","affiliation":[{"name":"Department of Urology and Paediatric Urology University Medical Center Mainz 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