{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:17:53Z","timestamp":1787807873950,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Robotics Computer Surgery"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study assessed the real\u2010world hepatotoxicity of third\u2010generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FAERS data (Q1 2004\u2013Q1 2025) were analysed using a data\u2010driven disproportionality analysis framework incorporating traditional frequentist metrics and an information\u2010theoretic Bayesian network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 24 liver\u2010related adverse events and 7 clinical outcomes were extracted in this study. Letrozole associated with the highest number of hepatotoxicity cases and showed the highest BCPNN\u2010supported reporting signal. Exemestane exhibited the earliest hepatotoxicity onset (median 49\u00a0days), significantly earlier (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047) than anastrozole (61.5\u00a0days) and letrozole (56\u00a0days).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AIs present distinct hepatotoxic profiles. Exemestane requires early vigilance due to its rapid onset, while letrozole exhibits the highest signal. Proactive liver monitoring and individualised management are crucial. Future research should integrate artificial intelligence with multi\u2010modal real\u2010world data for predictive risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rcs.70216","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:52:30Z","timestamp":1785588750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signal Detection and Temporal Analysis of Aromatase Inhibitor\u2010Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief\u2010Propagation Network and Frequentist Metrics"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-5984","authenticated-orcid":false,"given":"Yuke","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy Hubei Cancer Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 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