{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:11:54Z","timestamp":1773659514560,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["25124707"],"award-info":[{"award-number":["25124707"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008801","name":"senri life science fundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008801","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regeneration"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limb regeneration is a representative phenomenon of organ regeneration in urodele amphibians, such as an axolotl. An amputated limb starts regenerating from a remaining stump (proximal) to lost finger tips (distal). In the present case, proximal\u2212distal (PD) reorganization takes place in a regenerating tissue, called a blastema. It has been a mystery how an induced blastema recognizes its position and restores an exact replica of missing parts. Recently, a new experimental system called the accessory limb model (ALM) has been established. The gained ALM phenotypes are demanding to reconsider the reorganization PD positional values. Based on the ALM phenotype, it is reasonable to hypothesize that reorganization of positional values has a certain discontinuity and that two different regeneration systems cooperatively reorganize the PD axis to restore an original structure. In this review, PD axis reestablishments are focused on limb regeneration. Knowledge from ALM studies in axolotls and <jats:italic>Xenopus<\/jats:italic> is providing a novel concept of PD axis reorganization in limb regeneration.<\/jats:p>","DOI":"10.1002\/reg2.16","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T14:16:10Z","timestamp":1409235370000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Implication of two different regeneration systems in limb regeneration"],"prefix":"10.1002","volume":"1","author":[{"given":"Aki","family":"Makanae","sequence":"first","affiliation":[{"name":"Okayama University Research Core for Interdisciplinary Sciences (RCIS)  3\u20101\u20101 Tsushimanaka Kitaku Okayama 700\u20138530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Mitogawa","sequence":"additional","affiliation":[{"name":"Okayama University Research Core for Interdisciplinary Sciences (RCIS)  3\u20101\u20101 Tsushimanaka Kitaku Okayama 700\u20138530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Satoh","sequence":"additional","affiliation":[{"name":"Okayama University Research Core for Interdisciplinary Sciences (RCIS)  3\u20101\u20101 Tsushimanaka Kitaku Okayama 700\u20138530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2007.00919.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100922"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402020102"},{"key":"e_1_2_10_5_1","first-page":"887","article-title":"Vertebrate limb regeneration and the origin of limb stem cells","volume":"46","author":"Bryant S.V.","year":"2002","journal-title":"Int. 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