{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:38:15Z","timestamp":1790552295898,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"am","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T00:00:00Z","timestamp":1503187200000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006754","name":"Army Research Laboratory","doi-asserted-by":"publisher","award":["W911NF-09-1-0305"],"award-info":[{"award-number":["W911NF-09-1-0305"]}],"id":[{"id":"10.13039\/100006754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF-06-1-0161"],"award-info":[{"award-number":["W911NF-06-1-0161"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regeneration"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regeneration of mammalian limbs is restricted to amputation of the distal digit tip, the terminal phalanx (P3). The adjacent skeletal element, the middle phalanx (P2), has emerged as a model system to investigate regenerative failure and as a site to test approaches aimed at enhancing regeneration. We report that exogenous application of bone morphogenetic protein 2 (BMP2) stimulates the formation of a transient cartilaginous callus distal to the amputation plane that mediates the regeneration of the amputated P2 bone. BMP2 initiates a significant regeneration response during the periosteal\u2010derived cartilaginous healing phase of P2 bone repair, yet fails to induce regeneration in the absence of periosteal tissue, or after boney callus formation. We provide evidence that a temporal component exists in the induced regeneration of P2 that we define as the \u201cregeneration window.\u201d In this window, cells are transiently responsive to BMP2 after the amputation injury. Simple re\u2010injury of the healed P2 stump acts to reinitiate endogenous bone repair, complete with periosteal chondrogenesis, thus reopening the \u201cregeneration window\u201d and thereby recreating a regeneration\u2010permissive environment that is responsive to exogenous BMP2 treatment.<\/jats:p>","DOI":"10.1002\/reg2.81","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:22:38Z","timestamp":1496794958000},"page":"140-150","source":"Crossref","is-referenced-by-count":43,"title":["The periosteal requirement and temporal dynamics of BMP2\u2010induced middle phalanx regeneration in the adult mouse"],"prefix":"10.1002","volume":"4","author":[{"given":"Lindsay A.","family":"Dawson","sequence":"first","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M\u00a0University  4466 TAMU College Station TX USA"},{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M\u00a0University  4466 TAMU College Station TX USA"},{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Yan","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M\u00a0University  4466 TAMU College Station TX USA"},{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-2133","authenticated-orcid":false,"given":"Luis","family":"Marrero","sequence":"additional","affiliation":[{"name":"Department of Medicine Louisiana State\u00a0University\u00a0Health Sciences Center  New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula P.","family":"Schanes","sequence":"additional","affiliation":[{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Dolan","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M\u00a0University  4466 TAMU College Station TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maegan","family":"Pela","sequence":"additional","affiliation":[{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Petersen","sequence":"additional","affiliation":[{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjong","family":"Han","sequence":"additional","affiliation":[{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-6869","authenticated-orcid":false,"given":"Ken","family":"Muneoka","sequence":"additional","affiliation":[{"name":"Veterinary Physiology and Pharmacology Texas A&amp;M\u00a0University  4466 TAMU College Station TX USA"},{"name":"Cell and Molecular Biology Tulane University  2000 Percival Stern Hall, 6400 Freret St New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905851106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0257"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33599"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0550"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0036"},{"issue":"12","key":"e_1_2_6_7_1","first-page":"2116","article-title":"Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis","volume":"2","author":"Bandyopadhyay A.","year":"2006","journal-title":"Public Library of Science Genetics"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.04.016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100922"},{"key":"e_1_2_6_10_1","volume-title":"Principles of Regenerative Biology","author":"Carlson B. M.","year":"2007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.51"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.08.023"},{"issue":"2","key":"e_1_2_6_15_1","first-page":"86","article-title":"Conservative management of guillotine amputation of the finger in children","volume":"8","author":"Douglas B. S.","year":"1972","journal-title":"Australian Paediatric Journal"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-006-0066-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-200511101-00002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.016"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.11.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00710"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.12.025"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0148"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-016-0780-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23728"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198901000-00038"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80220-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10546"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24330"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.07.020"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118017108"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2007.00909.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.29"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.39"},{"issue":"3","key":"e_1_2_6_34_1","first-page":"e59105","article-title":"Regeneration of soft tissues is promoted by MMP1 treatment after digit amputation in mice","volume":"8","author":"Mu X.","year":"2013","journal-title":"Public Library of Science One"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092110207"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092230412"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00008-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0515"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-140-36557"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10346"},{"issue":"10","key":"e_1_2_6_41_1","first-page":"e0140156","article-title":"Hyperbaric oxygen promotes proximal bone regeneration and organized collagen composition during digit regeneration","volume":"10","author":"Sammarco M. C.","year":"2015","journal-title":"Public Library of Science One"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00066-6"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2010.01214.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v015a05"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.36"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.34"},{"key":"e_1_2_6_47_1","doi-asserted-by":"crossref","unstructured":"Simkin J. Sammarco M. C. Marrero L. Dawson L. A. Yan M. Tucker C. \u2026Muneoka K.(2017).Macrophages are required to coordinate mouse digit tip regeneration. DevelopmentSubmitted.","DOI":"10.1101\/104356"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12214"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.038"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1916"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.10.178"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"issue":"1","key":"e_1_2_6_54_1","first-page":"e54764","article-title":"Connective tissue fibroblast properties are position\u2010dependent during mouse digit tip regeneration","volume":"8","author":"Wu Y.","year":"2013","journal-title":"Public Library of Science One"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.042424"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.09.021"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.03.012"}],"container-title":["Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Freg2.81","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/reg2.81","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/reg2.81","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1002%2Freg2.81","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/reg2.81","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/reg2.81","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T19:41:27Z","timestamp":1696448487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/reg2.81"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/reg2.81"],"URL":"https:\/\/doi.org\/10.1002\/reg2.81","archive":["Portico"],"relation":{},"ISSN":["2052-4412","2052-4412"],"issn-type":[{"value":"2052-4412","type":"print"},{"value":"2052-4412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}