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However, its long\u2010term prognostic value across different ILD aetiologies remains unclear. This study aimed to assess the predictive performance of CPET\u2010derived parameters for long\u2010term outcomes in patients with idiopathic pulmonary fibrosis (IPF) and connective tissue disease\u2010associated ILD (CTD\u2010ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, 210 patients newly diagnosed with ILD between 2018 and 2022 at a tertiary medical centre underwent CPET. A CPET\u2010derived summed score was evaluated for its association with a composite outcome of all\u2010cause mortality or lung transplantation. Cox regression and receiver operating characteristic curve analyses were used to examine predictive ability and identify the optimal cutoff value. Kaplan\u2013Meier survival analysis and log\u2010rank tests compared event\u2010free survival in IPF and CTD\u2010ILD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A summed score incorporating five CPET\u2010derived variables was an independent predictor of the composite outcome. Patients with scores of 2\u20135 had markedly lower event\u2010free survival (44.2%) than those with scores of 0\u20131 (88.3%). The score demonstrated consistent predictive value in both IPF and CTD\u2010ILD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CPET\u2010derived summed score is a useful prognostic tool for predicting all\u2010cause mortality or the need for lung transplantation in newly diagnosed ILD patients. It also retains predictive accuracy for long\u2010term outcomes in both IPF and CTD\u2010ILD. External validation in other ILD subtypes is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT06476470\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70193-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70193","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T06:50:24Z","timestamp":1766472624000},"page":"498-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of a Cardiopulmonary Exercise Testing\u2010Derived Summed Score in Idiopathic Pulmonary Fibrosis and Connective Tissue Disease\u2010Associated Interstitial Lung Disease: A Prospective Cohort Study"],"prefix":"10.1002","volume":"31","author":[{"given":"Yu\u2010Lin","family":"Tsai","sequence":"first","affiliation":[{"name":"Integrated Care Centre of Interstitial Lung Disease Taichung Veterans General Hospital  Taichung City Taiwan"},{"name":"Division of Cardiopulmonary Rehabilitation, Department of Physical Medicine and Rehabilitation Taichung Veterans General Hospital  Taichung City Taiwan"},{"name":"Department of Industrial Engineering and Enterprise Information Tunghai 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