{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:45:34Z","timestamp":1777632334687,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CS\u20102018\u201018\u2010ST2\u2010004"],"award-info":[{"award-number":["CS\u20102018\u201018\u2010ST2\u2010004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006630","name":"Lung Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      In fibrotic lung disease, radiological features of usual interstitial pneumonia (UIP) are associated with adverse outcomes. The aim of this study was to evaluate the likelihood of definite UIP on HRCT as a determinant of outcome in patients with pulmonary fibrosis\n                      <jats:italic>.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All available HRCT from the Australian IPF Registry (AIPFR) were retrospectively reviewed by two radiologists. The radiologists were asked to assign a likelihood (%) within each of the four ATS\/ERS\/JRS\/ALAT 2018 UIP categories, summating to 100%, enabling them to not be constrained by a single UIP category (e.g., 5% definite UIP, 95% alternative to UIP). Likelihood of UIP was defined as the percentage likelihood score for the definite UIP category. Semi\u2010quantitative features were also estimated. Cox proportional hazards regression was performed to evaluate the prognostic utility of the likelihood scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HRCT was available for analysis in 515 patients. Median follow\u2010up of the cohort was 4.1\u2009years (IQR 2.0\u20136.2\u2009years). Median total ILD extent was 30% (IQR20\u201045%), with traction bronchiectasis and honeycombing present in 96.3% and 45.4% of cases respectively, and all three variables were associated with worse transplant\u2010free survival. A pattern of definite or probable UIP was favoured in 26.4% and 32.4% of cases respectively. Likelihood of definite UIP was independently associated\u00a0with\u00a0both reduced transplant\u2010free survival (HR1.12, 95% CI 1.04\u20131.20;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and 12\u2010month progression (HR1.19, 95% CI 1.04\u20131.35;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and was superior to the ATS\/ERS\/JRS\/ALAT 2018 guideline\u2010based categories for these associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We demonstrate that estimation of the likelihood of definite UIP is strongly associated with transplant\u2010free survival and 12\u2010month disease progression.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70196-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70196","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:49:50Z","timestamp":1767930590000},"page":"521-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Likelihood of Usual Interstitial Pneumonia: A Novel Approach to Prognosis for Pulmonary Fibrosis"],"prefix":"10.1002","volume":"31","author":[{"given":"John A.","family":"Mackintosh","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon L. F.","family":"Walsh","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Silva","sequence":"additional","affiliation":[{"name":"Scienze Radiologiche, Department of Medicine and Surgery (DiMeC) University of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Calandriello","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per immagini, Radioterapia oncologica ed Ematologia Fondazione Policlinico Universitario A. Gemelli, IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Radiology National Jewish Health  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Radiology National Jewish Health  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen E.","family":"Jo","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"},{"name":"Respiratory Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-2890","authenticated-orcid":false,"given":"Ian","family":"Glaspole","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"},{"name":"Department of Allergy and Respiratory Medicine Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-9928","authenticated-orcid":false,"given":"Christopher","family":"Grainge","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2065-4346","authenticated-orcid":false,"given":"Nicole","family":"Goh","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"},{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep  Melbourne Victoria Australia"},{"name":"University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M. A.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-1196","authenticated-orcid":false,"given":"Yuben","family":"Moodley","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"},{"name":"School of Medicine &amp; Pharmacology University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-1774","authenticated-orcid":false,"given":"Paul N.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"NHMRC Centre of Research Excellence in Pulmonary Fibrosis  Sydney Australia"},{"name":"Royal Adelaide Hospital Chest 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