{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:16:26Z","timestamp":1780395386928,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/687"],"award-info":[{"award-number":["19\/687"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003449","name":"Green Lane Research and Educational Fund","doi-asserted-by":"publisher","award":["21\/01\/4153"],"award-info":[{"award-number":["21\/01\/4153"]}],"id":[{"id":"10.13039\/501100003449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Sympathetic nerve activity is heightened in pulmonary arterial hypertension (PAH), promotes deleterious pulmonary vascular and right ventricular remodelling, and is associated with worsened exercise capacity and mortality. Pulmonary arterial baroreceptors, activated by increased pulmonary arterial pressure and distension, could drive muscle sympathetic nerve activity (MSNA) in pulmonary hypertension (PH). We hypothesised that pulmonary arterial baroreceptor unloading using nebulised iloprost as a pulmonary arterial vasodilator would lower MSNA in clinically stable treated PAH and chronic thromboembolic PH (CTEPH) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In eleven PH patients (9 PAH, 2 CTEPH; 6 female; age 54\u2009\u00b1\u200914\u2009years) common peroneal nerve microneurography was performed to record MSNA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) at baseline (10\u2009min) and immediately following iloprost nebulisation (10\u2009min). Concurrent measures of cardiorespiratory physiology and pulmonary haemodynamics (transthoracic echocardiography) were obtained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Iloprost reduced systolic pulmonary artery pressure (50\u2009\u00b1\u200919\u2009mmHg baseline vs. 44\u2009\u00b1\u200915\u2009mmHg iloprost;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040), and increased right ventricular outflow tract acceleration time (RVOT AT; 99\u2009\u00b1\u200915\u2009ms baseline vs. 117\u2009\u00b1\u200916\u2009ms iloprost;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Although no overall change was seen in MSNA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05), the magnitude of change in MSNA burst size was inversely associated with the increase in RVOT AT (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.667,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0133).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide evidence suggestive of possible pulmonary arterial baroreceptor influence of MSNA burst amplitude in some PH patients. Pulmonary arterial baroreceptor activation may be a contributory mechanism to adverse sympatho\u2010excitation in PH.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                      ACTRN12622000494730\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70207-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70207","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:37:56Z","timestamp":1770115076000},"page":"621-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sympatho\u2010Excitation in Pulmonary Hypertension: The Potential Role of Pulmonary Arterial Baroreceptors: An Acute Physiologic Intervention Study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-1123","authenticated-orcid":false,"given":"Michael J.","family":"Plunkett","sequence":"first","affiliation":[{"name":"Manaaki Manawa\u2014The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"},{"name":"Respiratory Medicine Auckland City Hospital, Health New Zealand  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L. 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