{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:57:13Z","timestamp":1790888233370,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201979"],"award-info":[{"award-number":["82201979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371805"],"award-info":[{"award-number":["82371805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502160"],"award-info":[{"award-number":["82502160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92474112"],"award-info":[{"award-number":["92474112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      The treatment of anti\u2010melanoma differentiation\u2010associated gene 5 antibody\u2010positive dermatomyositis with interstitial lung disease (MDA5\n                      <jats:sup>+<\/jats:sup>\n                      DM\u2010ILD) remains a significant clinical challenge. To compare the effectiveness and safety of upadacitinib (UPA) versus tofacitinib (TOFA) upon 6\u2010month lung transplantation\u2010free survival in newly diagnosed MDA5\n                      <jats:sup>+<\/jats:sup>\n                      DM\u2010ILD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multi\u2010centre cohort study in China enrolled MDA5\n                      <jats:sup>+<\/jats:sup>\n                      DM\u2010ILD patients treated from January 2020 to February 2025. Prevalent\/incident new users and non\u2010inferior design along with inverse probability treatment weighting (IPTW) were implemented to emulate randomized controlled trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the eligible cohort, a total of 106 patients were treated with UPA and 328 with TOFA. The crude 6\u2010month lung transplantation\u2010free survival rates were 71.7% (76\/106) in the UPA group and 67.4% (221\/328) in the TOFA group. In the IPTW\u2010adjusted cohort, UPA showed a trend toward higher survival than TOFA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.067), with a weighted risk difference of 10.3% (95% confidence interval \u22120.4% to 20.2%) meeting the non\u2010inferiority margin (non\u2010inferiority\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Sensitivity and subgroup analyses showed consistent results, with potentially greater benefit of UPA in incident JAK inhibitor users (as first\u2010line treatment), monotherapy recipients (without combination with other immunosuppressants except steroid), and those with rapidly progressive ILD. Safety profiles were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      UPA was found to be non\u2010inferior to TOFA in improving 6\u2010month lung transplantation\u2010free survival among patients with MDA5\n                      <jats:sup>+<\/jats:sup>\n                      DM\u2010ILD, with comparable safety.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70248-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70248","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:04:49Z","timestamp":1776258289000},"page":"721-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Upadacitinib Versus Tofacitinib in Anti\u2010\n                    <scp>MDA5<\/scp>\n                    \u2010Positive Dermatomyositis With Interstitial Lung Disease: A Multi\u2010Centre Cohort Study Emulating a Target Trial"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4501-3960","authenticated-orcid":false,"given":"Can","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saisai","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runci","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakai","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-0321","authenticated-orcid":false,"given":"Bingpeng","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical\u00a0Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0917-6785","authenticated-orcid":false,"given":"Qun","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical\u00a0Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-222X","authenticated-orcid":false,"given":"Qian","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical\u00a0Center for Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Second Affiliated Hospital of Zhejiang University, School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Immune Therapy Institute  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01054-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-020-08822-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.883699"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16917"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.023"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1900045"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01488-2024"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00458-2025"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13688"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01303-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18406"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003837"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.13350"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211468"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2019.10.005"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.10.004"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214690"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1859-x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_12_22_1","unstructured":"A.Kassambara M.Kosinski andP.Biecek \u201cSurvminer: Drawing Survival Curves Using \u2018ggplot2\u2019 (R Package Version 0.5.2) \u201d2026 https:\/\/rpkgs.datanovia.com\/survminer\/index.html."},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2025.100802"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X241250238"},{"key":"e_1_2_12_25_1","first-page":"251","article-title":"Triple\u2010Combination Therapy Did Not Improve Prognosis in Anti\u2010MDA5 Positive Dermatomyositis: A Multicentre Longitudinal Cohort Study","volume":"43","author":"You H.","year":"2025","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34145-4"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab305"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-020-00257-w"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.040"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00581-5"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30419-2"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31115-2"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31116-4"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1513"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X251393130"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01062-9"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01840-5"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-025-01188-7"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/resp.70248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/resp.70248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/resp.70248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:23:07Z","timestamp":1783480987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/resp.70248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/resp.70248"],"URL":"https:\/\/doi.org\/10.1002\/resp.70248","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}