{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:15:21Z","timestamp":1788340521479,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The diagnosis of mediastinal lymphoproliferative disorders (LPDs) is often challenging and requires histopathological assessment from large tissue samples. As a result, new diagnostic techniques have been introduced alongside the commonly used endobronchial ultrasound\u2010guided trans\u2010bronchial needle aspiration (EBUS\u2010TBNA). Among them, EBUS\u2010guided transbronchial mediastinal cryobiopsy (EBUS\u2010TBMC) has shown promising potential, although high\u2010quality evidence remains limited. The aim of the study was to assess the diagnostic yield of EBUS\u2010TBMC compared with EBUS\u2010TBNA in patients with suspected mediastinal LPDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicentre study enrolled patients with suspected mediastinal LPDs undergoing bronchoscopy with EBUS for mediastinal lymph node sampling. All participants had either B symptoms or a history of LPD. All patients underwent EBUS\u2010TBNA followed by EBUS\u2010TBMC from the same mediastinal lymph node. Final diagnoses were confirmed after a 6\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010eight patients underwent EBUS, of whom 50 completed both EBUS\u2010TBNA and EBUS\u2010TBMC. There were eight cases of failed EBUS\u2010TBMC who were not included in the analysis. The most frequent diagnoses were LPDs (54%) and sarcoidosis (30%). EBUS\u2010TBNA and EBUS\u2010TBMC had overall diagnostic yield of 52% and 80%, respectively. Among non\u2010diagnostic EBUS\u2010TBNA samples, 80% were diagnostic with EBUS\u2010TBMC (odds ratio 4.89, 95% CI 1.76\u201313.6). For confirmed LPDs, diagnostic yield was 41% for EBUS\u2010TBNA and 85% for EBUS\u2010TBMC. No major complications during or following the EBUS\u2010TBMC were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EBUS\u2010TBMC was superior to EBUS\u2010TBNA and achieved a high diagnostic yield in patients with suspected mediastinal LPDs.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/resp70274-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70274","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:30:37Z","timestamp":1781695837000},"page":"903-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Yield of\n                    <scp>EBUS<\/scp>\n                    Mediastinal Cryobiopsy Versus\n                    <scp>TBNA<\/scp>\n                    in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study"],"prefix":"10.1002","volume":"31","author":[{"given":"Yaniv","family":"Dotan","sequence":"first","affiliation":[{"name":"Pulmonary Institute, Rambam Health Care Campus and Ruth and Bruce Rappaport Faculty of Medicine  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayal","family":"Romem","sequence":"additional","affiliation":[{"name":"Pulmonary Department Meir Medical Center  Kfar Saba Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Guber","sequence":"additional","affiliation":[{"name":"Pulmonary Department Meir Medical Center  Kfar Saba Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kassirer","sequence":"additional","affiliation":[{"name":"Pulmonary Division Soroka Medical Center, Faculty of Medicine, Ben Gurion University  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Felus","sequence":"additional","affiliation":[{"name":"Pulmonary Institute, Rambam Health Care Campus and Ruth and Bruce Rappaport Faculty of Medicine  Haifa 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