{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:10:38Z","timestamp":1790788238981,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022M3A9E4082647"],"award-info":[{"award-number":["NRF\u20102022M3A9E4082647"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Prediction of the progressive phenotype from baseline evaluation is challenging due to the variable clinical course of fibrosing interstitial lung disease (ILD). The aim of this study was to evaluate whether the Single Time Point Prediction (STP) score predicts disease progression better than other quantitative scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective two\u2010centre study including patients with ILD other than idiopathic pulmonary fibrosis (IPF). Using an automated quantification system, quantitative lung fibrosis (QLF), quantitative ground\u2010glass opacity (QGG), quantitative ILD (QILD; the sum of reticulation, honeycombing, and ground\u2010glass opacity), quantitative normal lung (QNL), and STP scores were measured. Disease progression (DP) was defined as an absolute decline in forced vital capacity (FVC)\u2009\u2265\u20095% or DL\n                      <jats:sub>CO<\/jats:sub>\n                      \u2009\u2265\u200910% predicted, death or lung transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 245 patients, 137 (55.9%) progressed during follow\u2010up (median: 20.4\u2009months). In the Kaplan\u2013Meier analysis, patients with high QGG (\u2265\u200910%), high QILD (\u2265\u200930%), and high STP (\u2265\u200930%) showed shorter DP free survival time than those without. After adjusting for age, sex, FVC, and types of non\u2010IPF ILD, QGG scores \u2265\u200910%, QILD \u2265\u200930%, and STP \u2265\u200930% remained significant predictors of progression (hazard ratio [HR]\u2009=\u20091.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024; HR\u2009=\u20091.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006; and HR\u2009=\u20091.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020, respectively). Furthermore, higher QILD and QGG scores in STP\u2010positive regions were independently associated with increased DP risk, whereas higher QNL in STP\u2010negative regions was associated with lower DP risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The STP score is a useful imaging biomarker for predicting DP and, when combined with conventional quantitative CT scores, may improve risk stratification in patients with non\u2010IPF ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70299","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:05:18Z","timestamp":1786755918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CT<\/scp>\n                    \u2010Based Biomarkers for Predicting Progressive Phenotypes in Interstitial Lung Diseases: A Retrospective Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-3810","authenticated-orcid":false,"given":"Ju Hyun","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Ajou University Medical Center, Ajou University School of Medicine  Suwon Republic of Korea"},{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-3522","authenticated-orcid":false,"given":"Jin Woo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Goldin","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-8936","authenticated-orcid":false,"given":"S. Samuel","family":"Weigt","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Immunology, Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7506-3975","authenticated-orcid":false,"given":"Augustine","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Allergy and Immunology, Department of Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1336-8452","authenticated-orcid":false,"given":"Jared D.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease and Lung Transplant Inova Fairfax Medical Center  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereidoun","family":"Abtin","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-7840","authenticated-orcid":false,"given":"Lila","family":"Pourzand","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Villegas","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihey","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-8111","authenticated-orcid":false,"given":"Kyungjong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-3489","authenticated-orcid":false,"given":"Grace Hyun J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiologic Science David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Department of Biostatistics Fielding School of Public Health at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1164\/rccm.202202-0399ST","article-title":"Idiopathic Pulmonary Fibrosis (An Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS\/ERS\/JRS\/ALAT Clinical Practice Guideline","volume":"205","author":"Raghu G.","year":"2022","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"19","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/jama.2024.3669","article-title":"Interstitial Lung Disease: A Review","volume":"331","author":"Maher T. 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