{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:20:45Z","timestamp":1787746845268,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200046"],"award-info":[{"award-number":["82200046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013262","name":"State Key Laboratory of Respiratory Disease","doi-asserted-by":"publisher","award":["SKLRD\u2010Z\u2010202203"],"award-info":[{"award-number":["SKLRD\u2010Z\u2010202203"]}],"id":[{"id":"10.13039\/100013262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110233"],"award-info":[{"award-number":["2022A1515110233"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Non\u2010invasive ventilation (NIV) is the first\u2010line treatment for acute pulmonary edema (APE).\u00a0However, with the development of high\u2010flow nasal cannula oxygen therapy (HFNC), recent small\u2010sample prospective\u00a0studies\u00a0have suggested comparable efficacy between HFNC and NIV in treating acute cardiogenic pulmonary edema.\u00a0To\u00a0further evaluate the efficacy of these two respiratory support modalities, we directly compared their outcomes using data from two public databases, aiming to provide higher\u2010quality evidence on the differences in benefit between the treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with APE and treated with NIV or HFNC were identified from the MIMIC\u2010IV and eICU databases. Relevant demographics, vital signs, clinical outcomes, and other metrics were extracted. The primary outcome was the respiratory rate (RR) at 1 h post\u2010treatment. The secondary outcomes were the 7\u2010day intubation rate, 28\u2010day mortality, and intensive care unit length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 1180 patients were included in the study (161 in the HFNC group and 1019 in the NIV group). After\u00a0propensity\u00a0score matching, 158 patients were included in each group for analysis. There was no statistically significant\u00a0difference\u00a0in\u00a0the\u00a0RR at 1 h post\u2010treatment between the NIV and HFNC groups (21 vs. 22 beats\/min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The 7\u2010day\u00a0intubation\u00a0rate\u00a0was significantly lower in the NIV group (8.23%; 13\/158) than in the HFNC group (28.48%; 45\/158) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort study using propensity score matching, there was no statistically significant difference in RR at 1 h post\u2010treatment between patients treated with HFNC or NIV for APE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70304","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:39:28Z","timestamp":1787744368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Efficacy Between Non\u2010Invasive Ventilation and High\u2010Flow Nasal Cannula Oxygen Therapy in Treating Acute Pulmonary Edema"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-7524","authenticated-orcid":false,"given":"Qiaoyun","family":"Huang","sequence":"first","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyi","family":"Niu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zha","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-4622","authenticated-orcid":false,"given":"Luqian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchang","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Hetao Institute of Guangzhou National Laboratory  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Guan","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Respiratory Mechanics Laboratory, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, First Affiliated Hospital of Guangzhou Medical University  Guangzhou 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