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Although this clinicopathologic enrichment has been recognized for more than two decades, the mechanisms underlying the excess frequency of\n                    <jats:italic>EGFR<\/jats:italic>\n                    \u2010mutant disease in Asian populations remain only partially understood. Accumulating evidence suggests a multifactorial basis involving host genetic susceptibility and diversity, endogenous mutational processes and exogenous exposures such as ambient particulate matter. In particular, recent genomic and experimental studies support a tumour\u2010promotion framework in which inflammatory microenvironmental cues may facilitate the outgrowth of pre\u2010existing oncogenic clones, while mutational signatures provide genomic footprints of these processes. In parallel, the treatment landscape for\n                    <jats:italic>EGFR<\/jats:italic>\n                    \u2010mutant non\u2010small cell lung cancer has evolved substantially with successive generations of EGFR tyrosine kinase inhibitors (EGFR\u2010TKIs), leading to marked improvements in survival. However, acquired resistance remains inevitable in most patients with advanced disease and is driven by both genetic and non\u2010genetic mechanisms, including secondary\n                    <jats:italic>EGFR<\/jats:italic>\n                    alterations, bypass pathway activation,\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010associated genomic instability, adaptive mutagenesis, and drug\u2010tolerant persister states. These insights have provided a strong rationale for combination strategies beyond EGFR\u2010TKI monotherapy. In this review, we summarize current understanding of the epidemiology and biological basis of\n                    <jats:italic>EGFR<\/jats:italic>\n                    \u2010mutant lung cancer in Asia and discuss the preclinical rationale and emerging clinical evidence supporting combination approaches with chemotherapy, anti\u2010angiogenic agents, and EGFR\/MET\u2010directed therapies.\n                  <\/jats:p>","DOI":"10.1002\/resp.70315","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:01:18Z","timestamp":1789603278000},"page":"959-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting\n                    <i>EGFR<\/i>\n                    \u2010Mutant Non\u2010Small Cell Lung Cancer in Asia: An Update on Monotherapy and Combination Therapy\u00a0With\n                    <scp>EGFR<\/scp>\n                    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