{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:58:29Z","timestamp":1790823509917,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>\n                      Endobronchial valve (EBV) placement reduces hyperinflation in patients with severe COPD. Eligibility criteria of EBV include total lung capacity (TLC\n                      <jats:sub>pleth<\/jats:sub>\n                      ) \u2265\u2009100% and residual volume (RV\n                      <jats:sub>pleth<\/jats:sub>\n                      ) \u2265\u2009175% by body plethysmography. In this study, we evaluated the performance of alternative modalities for predicting EBV criteria in clinical settings where body plethysmography is unavailable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a single centre observational study. We recruited 41 patients with COPD at St. Marianna University Hospital. The participants underwent spirometry for VC, FVC, and FEV\n                      <jats:sub>1<\/jats:sub>\n                      , body plethysmography for TLC\n                      <jats:sub>pleth<\/jats:sub>\n                      and RV\n                      <jats:sub>pleth<\/jats:sub>\n                      , and the helium dilution technique for TLC\n                      <jats:sub>He<\/jats:sub>\n                      and RV\n                      <jats:sub>He<\/jats:sub>\n                      as well as CT scanning at full inspiration and expiration to calculate air volume (AV) and total lung volume (TLV), which includes both air and tissue volumes. We also estimated TLV\n                      <jats:sub>pleth<\/jats:sub>\n                      and RV\n                      <jats:sub>pleth<\/jats:sub>\n                      by using previously proposed formulas from the University of Groningen (TLC\n                      <jats:sub>Groningen<\/jats:sub>\n                      and RV\n                      <jats:sub>Groningen<\/jats:sub>\n                      ) and from the University of Pittsburgh (RV\n                      <jats:sub>Pittsburgh<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The alternative measurements, that is, TLC\n                      <jats:sub>He<\/jats:sub>\n                      , AV\n                      <jats:sub>inspiratory CT<\/jats:sub>\n                      , TLV\n                      <jats:sub>inspiratory CT<\/jats:sub>\n                      , TLC\n                      <jats:sub>Groningen<\/jats:sub>\n                      , RV\n                      <jats:sub>He<\/jats:sub>\n                      , AV\n                      <jats:sub>inspiratory CT<\/jats:sub>\n                      \u2013 VC, AV\n                      <jats:sub>expiratory CT<\/jats:sub>\n                      , TLV\n                      <jats:sub>inspiratory CT<\/jats:sub>\n                      \u2013 VC, TLV\n                      <jats:sub>expiratory CT<\/jats:sub>\n                      , RV\n                      <jats:sub>Groningen<\/jats:sub>\n                      , and RV\n                      <jats:sub>Pittsburgh<\/jats:sub>\n                      , correlated well with TLC\n                      <jats:sub>pleth<\/jats:sub>\n                      and RV\n                      <jats:sub>pleth<\/jats:sub>\n                      . Receiver operating characteristic analysis to predict TLC\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009100%, RV\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009175%, or RV\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009150% by these alternatives yielded high area under the curve (AUC) values around 0.924\u20130.937. We also determined the threshold values for sensitivity\u2009=\u2009100% (Rule\u2010out threshold) and specificity\u2009=\u2009100% (Rule\u2010in threshold) to predict TLC\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009100%, RV\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009175%, or RV\n                      <jats:sub>pleth<\/jats:sub>\n                      \u2009\u2265\u2009150%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that, when body plethysmography is not feasible, these measurements may help identify patients likely or unlikely to meet plethysmography\u2010defined EBV eligibility criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70321","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:33:29Z","timestamp":1790822009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of Total Lung Capacity and Residual Volume Eligibilities for Endobronchial Valve Treatment Using Measurements by the Helium Dilution Technique,\n                    <scp>CT<\/scp>\n                    \u2010Based Lung Volume Analysis, and Spirometry"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-5844","authenticated-orcid":false,"given":"Daisuke","family":"Kinose","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Shiga University of Medical Science  Otsu City Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shiga University of Medical Science  Otsu City Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-6579","authenticated-orcid":false,"given":"Masamichi","family":"Mineshita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Marianna University School of Medicine  Kawasaki City Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201c2025 GOLD Report\u2014Global Initiative for Chronic Obstructive Lung Disease\u2014GOLD\u201d https:\/\/goldcopd.org\/2025\u2010gold\u2010report\/# accessed 31 August 2025."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA0900928"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00161611"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)60001\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1507807"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201707\u20101327OC"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.201803\u20100590OC"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607\u20101383OC"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.15326\/JCOPDF.6.1.2018.0147"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01519\u20102022"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARBRES.2025.01.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.15326\/JCOPDF.2022.0354"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005S1693"},{"issue":"10","key":"e_1_2_11_15_1","first-page":"837","article-title":"Pulmonary Function and Its Prediction Equations in Healthy Subjects. 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