{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:35:27Z","timestamp":1792989327340,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["299901"],"award-info":[{"award-number":["299901"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1021275"],"award-info":[{"award-number":["1021275"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012503","name":"Royal Hobart Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018798","name":"Helen Macpherson Smith Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Whether lifetime lung function trajectories and spirometry patterns are associated with Obstructive Sleep Apnoea (OSA) is unknown. We aimed to investigate this association to widen the understanding of OSA pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We previously identified six FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC (forced expiratory volume in the first second\/forced vital capacity) and five FVC trajectories within a population\u2010based prospective cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092422) using spirometry assessed at ages 7, 13, 18, 43, 50, and 53\u2009years. These trajectories were combined into four lifetime spirometry patterns: restrictive\u2010only, obstructive\u2010only, mixed, and reference (normal), which were our exposure variables. Outcomes were medically\u2010confirmed OSA in midlife and probable\u2010OSA defined using the STOP\u2010Bang questionnaire. Associations were assessed using logistic regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The \u2018restrictive\u2010only\u2019 spirometry pattern was associated with medically\u2010confirmed OSA (OR\u2009=\u20092.5; 95% CI 1.5, 4.3). In addition, restriction\u2010confirmatory low total lung capacity and reduced functional residual capacity were associated with increased odds of medically\u2010confirmed OSA (OR\u2009=\u20091.4; 0.9, 2.1 and OR\u2009=\u20091.7; 1.1, 2.6, respectively, per one SD reduction in volume). The results were similar for probable OSA. These associations held when controlled for BMI and central obesity and were independent of childhood lung function. Neither transfer factor for carbon monoxide (T\n                      <jats:sub>L<\/jats:sub>\n                      co) nor transfer coefficient (Kco) was associated with OSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We provide first evidence that lifetime lung restriction is related to middle\u2010age OSA. While this information may be used to incidentally flag middle\u2010age OSA risk and vice versa, further research is encouraged to confirm the underlying pathophysiological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/resp.70326","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:30:42Z","timestamp":1792459842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lung Restriction From Childhood Is Associated With Obstructive Sleep Apnoea in Middle\u2010Age"],"prefix":"10.1002","author":[{"given":"Chamara V.","family":"Senaratna","sequence":"first","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"},{"name":"Institute for Health and Sport, Victoria University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-784X","authenticated-orcid":false,"given":"Dinh S.","family":"Bui","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-0615","authenticated-orcid":false,"given":"Jennifer L.","family":"Perret","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"},{"name":"Institute for Breathing and Sleep (IBAS), Heidelberg  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-3888","authenticated-orcid":false,"given":"Caroline J.","family":"Lodge","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-8162","authenticated-orcid":false,"given":"Adrian J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-0538","authenticated-orcid":false,"given":"Michael J.","family":"Abramson","sequence":"additional","affiliation":[{"name":"School of Public Health &amp; Preventive Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bircan","family":"Erbas","sequence":"additional","affiliation":[{"name":"School of Psychology and Public Health, La Trobe University  Bundoora Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-8766","authenticated-orcid":false,"given":"Paul","family":"Thomas","sequence":"additional","affiliation":[{"name":"Prince of Wales' Clinical School, Faculty of Medicine, University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-0796","authenticated-orcid":false,"given":"Robert","family":"Adams","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-6850","authenticated-orcid":false,"given":"David P.","family":"Johns","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-1869","authenticated-orcid":false,"given":"Yaoyao","family":"Qian","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Washko","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-4374","authenticated-orcid":false,"given":"E. Haydn","family":"Walters","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"},{"name":"The University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-2839","authenticated-orcid":false,"given":"Garun S.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Lung, Sleep, Allergy &amp; Immunology, Monash Health  Clayton Victoria Australia"},{"name":"School of Clinical Sciences, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-1937","authenticated-orcid":false,"given":"Shyamali C.","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health, Melbourne School of Population and Global Health, The University of Melbourne  Carlton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.04.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0785-0"},{"key":"e_1_2_11_4_1","first-page":"265","article-title":"Obstructive Sleep Apnea and Asthma","volume":"34","author":"Razak M. R. A.","year":"2016","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.02.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1614PP"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13616"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-6-S1-S5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2017.08.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-020-02086-1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30100-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00364-2"},{"key":"e_1_2_11_13_1","first-page":"407","article-title":"Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)","volume":"46","author":"Matheson M. C.","year":"2016","journal-title":"International Journal of Epidemiology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02232.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-213389"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00010-2017"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31816d83e4"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50145"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14592"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00214-2020"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086801"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1195OC"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2016.05.003"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9804140"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.5.2124"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00716.2012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00660.2018"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200404-552OC"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2510ST"},{"key":"e_1_2_11_35_1","first-page":"103","article-title":"Factors Affecting Growth of FEV1","volume":"59","author":"Bakke P.","year":"2003","journal-title":"Monaldi Archives for Chest Disease"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7427"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30434-4"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9609015"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-009-0263-5"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/resp.70326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/resp.70326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/resp.70326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:18:34Z","timestamp":1792988314000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/resp.70326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":38,"alternative-id":["10.1002\/resp.70326"],"URL":"https:\/\/doi.org\/10.1002\/resp.70326","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"resp.70326"}}