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In vitro maturation (\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      ), an important technique in\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      , has started to be used in the clinic, but controversies persist regarding this technique. Here, a survey of\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      for\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      is provided.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Based on a literature review, the applications of\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      , methods of\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      of oocytes that had been collected in vivo and ex vivo, maturation of oocytes after\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      for\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      , cryopreservation of oocytes for\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      , explanation of the procedures to patients, and recent research on\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      using\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      were investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      for\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      remains controversial, the application of\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      is expected to expand. Depending on the age and disease status of the patient, various methods of oocyte collection and ovarian stimulation, as well as various needle types and aspiration pressures, have been reported. The maturation rate of\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      ranges widely and requires optimization in the future. In regard to cryopreservation for matured oocytes, the vitrification method is currently recommended.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Regarding\n                      <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\n                      for patients with cancer, the treatment of cancer is prioritized; thus, the time and use of medicines are often constrained. As several key points regarding\n                      <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>\n                      remain unclear, well\u2010designed and specific counseling for patients is necessary.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12042","type":"journal-article","created":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T22:26:37Z","timestamp":1497824797000},"page":"258-267","source":"Crossref","is-referenced-by-count":41,"title":["In vitro maturation of human immature oocytes for fertility preservation and research material"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-0037","authenticated-orcid":false,"given":"Hiromitsu","family":"Shirasawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Akita University Graduate School of Medicine  Akita 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