{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:14:15Z","timestamp":1758125655594,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Society for the Promotion of Science KAKENHI Grant","award":["24592472","24592473"],"award-info":[{"award-number":["24592472","24592473"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Exposure to various stressors, including psychological, metabolic, and immune, in the perinatal period induces long\u2010lasting effects in physiological function and increase the risk of metabolic disorders in later life. In the present study, sexual maturation and sexual behavior were assessed in prenatally undernourished mature male rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the pregnant rats were divided into the maternal normal nutrition (<jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content>) group and the maternal undernutrition (<jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content>) group. The <jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content> mothers received 50% of the amount of the daily food intake of the <jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content> mothers. Preputial separation and sexual behavior were observed in randomly selected pups of the <jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content> groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The body weight of the mothers was significantly lighter in the <jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content> group. Similarly, the pups in the <jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content> group showed a significantly lower body weight than those in the <jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content> group from postnatal day (<jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content>) 1 to <jats:styled-content style=\"fixed-case\">PND<\/jats:styled-content> 15. The preputial separation day was significantly delayed in the <jats:styled-content style=\"fixed-case\">mUN<\/jats:styled-content> group, compared to the <jats:styled-content style=\"fixed-case\">mNN<\/jats:styled-content> group. Sexual behavior did not show any significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicated that prenatal undernutrition delayed sexual maturation, but did not suppress sexual behavior, in mature male rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12045","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:02:55Z","timestamp":1505743375000},"page":"325-329","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal undernutrition disrupted the sexual maturation, but not the sexual behavior, in male rats"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-1507","authenticated-orcid":false,"given":"Toshiya","family":"Matsuzaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University  Tokushima 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