{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:03:08Z","timestamp":1791932588661,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Case<\/jats:title><jats:p>A case of Leydig cell tumor, associated with azoospermia, is presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>The levels of sex hormones obviously were decreased, including luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) and follicle\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content>), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. He received a right radical orchiectomy and then he was unable to ejaculate. An endocrine panel revealed significantly decreased levels of testosterone and the low <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> level had remained. Hormone replacement therapy with combined <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> successfully recovered and preserved spermatogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the patient\u2019s sexual function deteriorated after surgery, hormone replacement therapy was successful in establishing spermatogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12046","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T09:37:38Z","timestamp":1500543458000},"page":"392-395","source":"Crossref","is-referenced-by-count":8,"title":["Leydig cell tumor of the testis, presenting with azoospermia"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9579-7064","authenticated-orcid":false,"given":"Hatsuki","family":"Hibi","sequence":"first","affiliation":[{"name":"Department of Urology Kyoritsu General Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Urology Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-9953","authenticated-orcid":false,"given":"Yoshimasa","family":"Asada","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.05.077"},{"key":"e_1_2_6_3_1","first-page":"777","article-title":"Testicular Leydig cell tumor presenting as male infertility: a case report","volume":"55","author":"Shiraishi Y","year":"2009","journal-title":"Hinyoukika Kiyo"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del468"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-016-0041-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-656"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40917-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01278.x"},{"key":"e_1_2_6_9_1","first-page":"60","article-title":"Unilateral malignant Leydig cell tumor of testis in a patient with contralateral cryptorchidism","volume":"6","author":"Efthimiou I","year":"2009","journal-title":"Urol J"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmb2.12046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:23:39Z","timestamp":1696170219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,20]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/rmb2.12046"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12046","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,20]]}}}