{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:27:01Z","timestamp":1740137221632,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Cases<\/jats:title><jats:p>Microdissection testicular sperm extraction (micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content>) was performed on five Japanese men with non\u2010mosaic Klinefelter's syndrome (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) and non\u2010obstructive azoospermia in the authors' department. Here is reported the operative results and partner's clinical course for two cases where spermatozoa could be acquired. Also encountered was a man with non\u2010mosaic <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> with the partial deletion of azoospermia factor (<jats:styled-content style=\"fixed-case\">AZF<\/jats:styled-content>)b. Because this is rare, it is reported in detail in the context of the previous literature. This case series describes the first experience of micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content> by gynecologists in the current department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>The egg collection date was adjusted to the micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content> day by using the modified ultra\u2010long method. Intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>) was implemented for two men whose spermatozoa were acquired by micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content>, with these progressing to the blastocyst stage. Subsequently, one case conceived after the transfer of fresh embryos and a healthy baby was delivered. However, spermatozoa could not be retrieved from the man with non\u2010mosaic <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> who was harboring the partial deletion of <jats:styled-content style=\"fixed-case\">AZF<\/jats:styled-content>b.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that ovulation induction by using the modified ultra\u2010long method with micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> on the same day represents an effective treatment option for men with non\u2010mosaic <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>. As there are cases where <jats:styled-content style=\"fixed-case\">AZF<\/jats:styled-content> deletion is recognized among patients with non\u2010mosaic <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>, screening before micro\u2010<jats:styled-content style=\"fixed-case\">TESE<\/jats:styled-content> is strongly recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12092","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T09:02:44Z","timestamp":1520499764000},"page":"209-216","source":"Crossref","is-referenced-by-count":5,"title":["Microdissection testicular sperm extraction in five Japanese patients with non\u2010mosaic Klinefelter's syndrome"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-7756","authenticated-orcid":false,"given":"Makoto","family":"Chihara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanna","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Godo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takakuwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.4.946"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2015.07.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02830-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01793-9"},{"key":"e_1_2_6_7_1","first-page":"421","article-title":"Outcomes of micro\u2010dissection TESE in patients with non\u2010mosaic Klinefelter's syndrome without hormonal treatment","volume":"8","author":"Ozveri H","year":"2015","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.05.019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det046"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.108"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2013.54.8.536"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2006.00083.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.November.25.2"},{"key":"e_1_2_6_14_1","unstructured":"Promega. 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