{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:43:03Z","timestamp":1792633383445,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To investigate the relationship between the meiotic spindle size in human metaphase\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      oocytes and embryo developmental potential after intracytoplasmic sperm injection (\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Analyzed were 1302 oocytes with a visible meiotic spindle from 281 patients aged under 40\u00a0years undergoing\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      cycles. The meiotic spindle was imaged by using PolScope before\n                      <jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>\n                      . The oocytes were classified into three groups, according to spindle size: group A (&lt;90\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ), group B (90\u2010120\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ), and group C (&gt;120\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 389 (29.9%) oocytes were classified into group A, 662 (50.8%) into group B, and 251 (19.3%) into group C. The fertilization rate of the group B oocytes was significantly higher than for the A and C oocytes. The blastocyst formation rate in group B was significantly higher than in group A. In addition, the pregnancy rate in group B was significantly higher than in the other two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The oocytes with a spindle size of 90\u2010120\u00a0\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      showed higher fertilization, blastocyst formation, and clinical pregnancy rates than those with larger or smaller spindles. The measurement of the meiotic spindle size thus has a positive predictive value for identifying human embryo developmental potential clinically.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12100","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T19:07:04Z","timestamp":1523387224000},"page":"268-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Meiotic spindle size is a strong indicator of human oocyte quality"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8085-4214","authenticated-orcid":false,"given":"Hiroyuki","family":"Tomari","sequence":"first","affiliation":[{"name":"IVF Nagata Clinic  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Honjo","sequence":"additional","affiliation":[{"name":"IVF Nagata Clinic  Fukuoka 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