{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:16:08Z","timestamp":1762161368498,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine & Biology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>To determine whether the cycle regimens that are used for endometrial preparation are associated with the birthweight (BW<\/jats:styled-content>) after assisted reproductive technology (ART<\/jats:styled-content>) using frozen\u2010thawed embryo transfer (FET<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>The BW<\/jats:styled-content> of singletons who were born by ART<\/jats:styled-content> using FET<\/jats:styled-content> was compared retrospectively, according to whether a FET<\/jats:styled-content> was conducted in a hormone replacement therapy cycle (HRT<\/jats:styled-content>, n\u00a0<\/jats:italic>=\u00a0403) or an ovulatory cycle (OVL<\/jats:styled-content>, n\u00a0=\u00a0117). The BW<\/jats:styled-content> after timed intercourse (NAT<\/jats:styled-content>, n\u00a0=\u00a0162) also was investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>There were no significant differences in the age of the mothers, percentage of primiparas, gestational periods, Body Mass Index, and sex ratio between the HRT<\/jats:styled-content> and OVL<\/jats:styled-content> cycles. The average BW<\/jats:styled-content> from HRT<\/jats:styled-content> was significantly greater than that of OVL<\/jats:styled-content>. The BW<\/jats:styled-content> from HRT<\/jats:styled-content> was also greater, compared with NAT<\/jats:styled-content>, while statistical significance was not achieved between OVL<\/jats:styled-content> and NAT<\/jats:styled-content>. The putative factors affecting the BW<\/jats:styled-content>, such as ovarian stimulation protocols, endometrial thickness, and the stage and quality of embryos, could not explain the difference in the BW<\/jats:styled-content> between the HRT<\/jats:styled-content> and OVL<\/jats:styled-content> cycles.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An increased BW<\/jats:styled-content> from ART<\/jats:styled-content> using FET<\/jats:styled-content> seems to be ascribable to conditions of the endometrium, but not cryopreservation procedures per se, which might provide a mechanistic framework for understanding heavier neonates who are born by FET<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12206","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T05:29:27Z","timestamp":1525670967000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-1066","authenticated-orcid":false,"given":"Rena","family":"Ishii","sequence":"first","affiliation":[{"name":"Women's Clinic Oizumi Gakuen Lenia Medical Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Shoda","sequence":"additional","affiliation":[{"name":"Women's Clinic Oizumi Gakuen Lenia Medical Corporation Tokyo 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