{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:43:43Z","timestamp":1781822623602,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Case<\/jats:title><jats:p>A 32\u00a0year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Therefore, selective ovarian venous sampling was performed. Consequently, the testosterone level was selectively increased in a blood sample that was taken from the left ovarian vein, the tumor was successfully localized, and a laparoscopic left oophorectomy was performed. Although the left ovary appeared to be normal at laparoscopy, the androgen\u2010secreting tumor was located within it. The tumor was diagnosed as a Leydig cell tumor by histopathological analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report demonstrates that selective blood sampling from ovarian veins before an operation is effective in localizing an androgen\u2010producing ovarian tumor that is difficult to diagnose by imaging studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12213","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T08:34:57Z","timestamp":1529570097000},"page":"504-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rare case of occult testosterone\u2010producing ovarian tumor that was diagnosed by selective venous hormone sampling"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-5579","authenticated-orcid":false,"given":"Yoshika","family":"Kuno","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizue","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3108"},{"key":"e_1_2_5_3_1","first-page":"75","volume-title":"Androgen excess disorders in women","author":"Pugeat M","year":"2006"},{"key":"e_1_2_5_4_1","first-page":"625","volume-title":"Pathology of the female reproductive tract","author":"Russell P","year":"2002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-6-43"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10040282.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.055"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-007-1032-5"},{"key":"e_1_2_5_9_1","first-page":"CS9","article-title":"Efficacy of selective venous catheterization in localizing a small androgen\u2010producing tumor in ovary","volume":"14","author":"NIshiyama S","year":"2008","journal-title":"Med Sci Monit"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00123.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02577904"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347121"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01792.x"},{"key":"e_1_2_5_14_1","first-page":"99","article-title":"Blockade of the in vitro effects of testosterone and erythropoietin on Cfu\u2010E and Bfu\u2010E proliferation by pretreatment of the donor rats with cyproterone and flutamide","volume":"48","author":"Malgor LA","year":"1998","journal-title":"Acta Physiol Pharmacol Ther Latinoam"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V31.4.453.453"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb15170.x"},{"key":"e_1_2_5_17_1","first-page":"442","article-title":"Erythropoietic mechanism of androgens: a critical review and clinical implications","volume":"67","author":"Molinari PF","year":"1982","journal-title":"Haematologica"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1182\/blood.V45.5.659.659","article-title":"Effects of erythropoietin on erythroid colony formation in uremic rabbit bone marrow cultures","volume":"45","author":"Moriyama Y","year":"1975","journal-title":"Blood"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0864"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jmh.JMH_81_17"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00405-0"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmb2.12213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T05:50:04Z","timestamp":1694929804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,21]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/rmb2.12213"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12213","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,21]]},"assertion":[{"value":"2018-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}