{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:09:23Z","timestamp":1791994163005,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine & Biology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Clomiphene citrate (\n CC<\/jats:styled-content>\n ) has been used as a first\u2010line treatment for anovulatory polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ). However, some patients with\n PCOS<\/jats:styled-content>\n are resistant to standard\n CC<\/jats:styled-content>\n treatment. In this study, a new\n CC<\/jats:styled-content>\n treatment protocol was developed, named \u201cintermittent\n CC<\/jats:styled-content>\n treatment\u201d (\n ICT<\/jats:styled-content>\n ) and its efficacy was investigated on the induction of follicular growth in patients with\n PCOS<\/jats:styled-content>\n who were resistant to standard\n CC<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Of the 42 patients with\n PCOS<\/jats:styled-content>\n who were resistant to standard\n CC<\/jats:styled-content>\n treatment (50\u00a0mg\/day, 5\u00a0days), 26 underwent\n ICT<\/jats:styled-content>\n . They were given 100\u00a0mg\/day of\n CC<\/jats:styled-content>\n for 5\u00a0days from the next menstrual cycle day (\n MCD<\/jats:styled-content>\n ) 5 (first\n CC<\/jats:styled-content>\n ). If follicular growth was not observed on\n MCD<\/jats:styled-content>\n 14, they were given 100\u00a0mg\/day of\n CC<\/jats:styled-content>\n for 5\u00a0days (\n MCD<\/jats:styled-content>\n 14\u2010\n MCD<\/jats:styled-content>\n 18) (second\n CC<\/jats:styled-content>\n ). If follicular growth still was not observed on\n MCD<\/jats:styled-content>\n 23, they were treated with\n CC<\/jats:styled-content>\n again in the same way (third\n CC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The first\n CC<\/jats:styled-content>\n , second\n CC<\/jats:styled-content>\n , and third\n CC<\/jats:styled-content>\n were effective for 3\/26 (11.5%) patients, 12\/23 (52.2%) patients, and 6\/11 (54.5%) patients, respectively. In total,\n ICT<\/jats:styled-content>\n was effective for 21\/26 (80.8%) patients with\n CC<\/jats:styled-content>\n \u2010resistant\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Thus,\n ICT<\/jats:styled-content>\n is a useful treatment and could be an alternative to gonadotropin therapy for patients with\n CC<\/jats:styled-content>\n \u2010resistant\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/rmb2.12219","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T02:44:06Z","timestamp":1530931446000},"page":"454-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Usefulness of intermittent clomiphene citrate treatment for women with polycystic ovarian syndrome that is resistant to standard clomiphene citrate treatment"],"prefix":"10.1002","volume":"17","author":[{"given":"Akihisa","family":"Takasaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-5556","authenticated-orcid":false,"given":"Isao","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Okada\u2010Hayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Orita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saiseikai Shimonoseki General Hospital Shimonoseki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2434"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei042"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02929-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2361"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-109"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw025"},{"issue":"9","key":"e_1_2_6_9_1","first-page":"CD010290","article-title":"Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome","author":"Weiss NS","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"510","key":"e_1_2_6_10_1","first-page":"e511","article-title":"Novel clomiphene \u201cstair\u2010step\u201d protocol reduces time to ovulation in women with polycystic ovarian syndrome","volume":"200","author":"Hurst BS","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12940"},{"key":"e_1_2_6_12_1","first-page":"868","article-title":"Constitute of reproductive endocrinology. Reports of a new diagnostic criteria of PCOS in Japan","volume":"59","author":"The Japanese Society of Obstetrics and Gynecology","year":"2007","journal-title":"Acta Obstet Gynaecol Jpn"},{"key":"e_1_2_6_13_1","first-page":"CD002249","article-title":"Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome","volume":"12","author":"Brown J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.10.2688"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.2.349"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.09.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.11.15006"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmb2.12219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T01:49:53Z","timestamp":1694915393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/rmb2.12219"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12219","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}