{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:31:26Z","timestamp":1769149886695,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The clinical utility of chlormadinone acetate tablets (Lutoral\u2122), an orally active progestin which has been available since June 2007, was compared to an in\u2010house vaginal suppository formulation of progesterone used between 2006 and 2007 for assisted reproductive technology (ART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated the efficacy and safety of chlormadinone acetate by comparing the pregnancy rates and the incidences of birth defects and hypospadias in frozen\u2010thawed embryo transfer cycles using the in\u2010house vaginal progesterone and those using chlormadinone acetate for luteal phase support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pregnancy rates in the frozen\u2010thawed embryo transfer cycles were 31.2% (259\/831) with vaginal progesterone for luteal phase support and 31.6% (4228\/13 381) with chlormadinone acetate (no significant difference). In the cycles resulting in live birth following administration of chlormadinone acetate between July 2007 and December 2015, the incidence of birth defects was 2.8% (80\/2893), and the incidence of hypospadias was 0.03% (1\/2893).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that the pregnancy rate following frozen\u2010thawed embryo transfer using chlormadinone acetate for luteal phase support was comparable with that using vaginal progesterone, with no increased risk of birth defects, including hypospadias, which has been a concern following the use of progestins.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12274","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T03:34:29Z","timestamp":1557459269000},"page":"290-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical utility of chlormadinone acetate (Lutoral\u2122) in frozen\u2010thawed embryo transfer with hormone replacement"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0448-9953","authenticated-orcid":false,"given":"Yoshimasa","family":"Asada","sequence":"first","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"},{"name":"Asada Institute for Reproductive Medicine Kasugai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hashiba","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Hattori","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Ito","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritaka","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"},{"name":"Asada Institute for Reproductive Medicine Kasugai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Sonohara","sequence":"additional","affiliation":[{"name":"Asada Ladies Clinic Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev339"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.064"},{"key":"e_1_2_9_4_1","unstructured":"Standard commodity classification no of Japan: 872478 [In Japanese].http:\/\/www.info.pmda.go.jp\/go\/pack\/2478001F1040_2_03\/"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0430412"},{"key":"e_1_2_9_6_1","first-page":"333","article-title":"Teratogenic study of delta 6, 6\u2010chloro\u201017\u2010alpha\u2010acetoxyprogesterone on the fetuses of castrated or intact doc rabbits (Fre)","volume":"28","author":"Chambron Y","year":"1967","journal-title":"Ann Endocrinol"},{"key":"e_1_2_9_7_1","unstructured":"SatoTet al. (editor).Jissen \u2010 Ninshin to Kusuri '92 [Practice \u2010 Drugs in Pregnancy]. Jihou. 1992 [in Japanese]."},{"key":"e_1_2_9_8_1","unstructured":"Australian Government: Department of Health\/Therapeutic Goods Administration.Australian categorisation system for prescribing medicines in pregnancy.https:\/\/www.tga.gov.au\/prescribing-medicines-pregnancy-database"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137355"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-121-30803"},{"key":"e_1_2_9_11_1","unstructured":"TamayaT.Sex steroid hormone ga wakaru [Sex steroid hormones]. Kinpodo 1999 [In Japanese]."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.095"},{"key":"e_1_2_9_13_1","unstructured":"FritzMA SperoffL.Clinical Gynecologic Endocrinology and Infertility.Philadelphia PALippincott Williams & Wilkins.2012;1163."},{"key":"e_1_2_9_14_1","unstructured":"The Japan Society of Pediatric Surgeons (JSPS).Disease to be treated with pediatric surgery\/genitourinary organ.http:\/\/www.jsps.gr.jp\/general\/disease\/gu\/"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6439a3"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmb2.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:08:11Z","timestamp":1694257691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/rmb2.12274"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12274","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]},"assertion":[{"value":"2018-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}