{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:05:55Z","timestamp":1791925555672,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Aeon International Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the effectiveness of intrauterine administration of platelet\u2010rich plasma (PRP) in frozen embryo transfer (FET) cycle in Japanese patients with a thin endometrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A prospective single\u2010arm self\u2010controlled trial was conducted in Japan. PRP administration was performed in 36 of the 39 eligible patients with a thin endometrium (\u22647\u00a0mm). Hormone replacement therapy (HRT) with estrogen was performed for 2 menstrual cycles, and PRP was administrated on the 10th and 12th days of the second HRT cycle. The endometrial thickness was evaluated on transvaginal ultrasonography by two physicians at every visit, one an attending physician and the other a specialist physician blinded to the date and timing of the sonography. FET was performed during the second HRT cycle after PRP administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After PRP administration, the mean (SD) endometrial thickness on the 14th day was significantly increased by 1.27\u00a0mm (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and 0.72\u00a0mm (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) on the basis of the unblinded and blinded measurements, respectively. Of the 36 patients, 32 (88.9%) underwent FET. The clinical pregnancy rate was 15.6%. No adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PRP therapy was safe and effective in increasing endometrial thickness improving possibly pregnancy rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12334","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T09:48:48Z","timestamp":1593078528000},"page":"350-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Intrauterine administration of platelet\u2010rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single\u2010arm self\u2010controlled trial"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-1986","authenticated-orcid":false,"given":"Maki","family":"Kusumi","sequence":"first","affiliation":[{"name":"Center for Human Reproduction and Gynecologic Endoscopy Sanno Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuji","family":"Ihana","sequence":"additional","affiliation":[{"name":"Center for Human Reproduction and Gynecologic Endoscopy Sanno Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Center for Human Reproduction and Gynecologic Endoscopy Sanno Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-4474","authenticated-orcid":false,"given":"Yasuo","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Integrated Science and Engineering for Sustainable Society Chuo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Director of Sanno Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12307"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265679"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg045"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.01.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137718"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt218"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01205.x"},{"key":"e_1_2_10_12_1","first-page":"1286","article-title":"Autologous platelet\u2010rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization","volume":"8","author":"Chang Y","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20170013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.10.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2019.1569268"},{"key":"e_1_2_10_16_1","unstructured":"Ministry of Health Labour and Welfare Japan.The act on the safety of regenerative medicine Act No. 85 of November 27 2013. Available at:https:\/\/www.mhlw.go.jp\/file\/06\u2010Seisakujouhou\u201010800000\u2010Iseikyoku\/0000030847.pdf. Accessed March 25 2020. (In Japanese)"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138509"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.10.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014062"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13254"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1130-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.08.007"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmb2.12334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:50:15Z","timestamp":1693828215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/rmb2.12334"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12334","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,25]]},"assertion":[{"value":"2020-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}