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Obtained uterine tissues and implantation sites were processed for immunofluorescence and real\u2010time PCR examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mRNA expression of MMP\u20107 was higher than MMP\u20102 and MMP\u20109. Immunofluorescence findings confirmed that MMP\u20102, MMP\u20107, and MMP\u20109 were localized in the endometrial stroma, while MMP\u20107 was high in glandular and lining epithelial cells throughout the entire estrous cycle. However, their immunolocalizations and mRNA expressions were dramatically changed with the early pregnancy days. The MMP\u20107 reached very strong immunostaining in the giant trophoblast cells (GTCs), and the cytoplasm of mature and differentiating decidual cells, whereas MMP\u20102 and MMP\u20109 were mostly seen in the primary decidual zone (PDZ), GTCs, and the endothelium of blood vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All three MMPs seemed likely to be a key mediator of trophoblast invasion into the decidual region as well as angiogenesis during the placentation process. Due to the strong and wide expression of MMP\u20107 in the mature decidua, it could be suggested that MMP\u20107 is important for decidual ECM remodeling and it might be used as a new marker of decidual reaction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12342","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T04:10:55Z","timestamp":1596773455000},"page":"385-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The regulation of trophoblast invasion and decidual reaction by matrix metalloproteinase\u20102, metalloproteinase\u20107, and metalloproteinase\u20109 expressions in the rat endometrium"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-5336","authenticated-orcid":false,"given":"Rasim","family":"Hamuto\u011flu","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine Cumhuriyet 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