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The strong connection between oxidative stress (OS) and male infertility has led recent investigators to propose the term \u201cMale Oxidative Stress Infertility (MOSI)\u201d to describe OS\u2010associated male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed database for original and review articles to survey the effects of OS on male infertility, and then verified the effects and treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main findings<\/jats:title><jats:p>Seminal plasma contains many antioxidants that protect sperm from ROS, because low amounts of ROS are required in the physiological fertilization process. The production of excessive ROS causes OS which can lower fertility through lipid peroxidation, sperm DNA damage, and apoptosis. Several assays are available for evaluating OS, including the MiOXSYS\u00ae analyzer to measure oxidation\u2010reduction potential. 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