{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:40:49Z","timestamp":1781887249936,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Since 2007, the Japan Society of Obstetrics and Gynecology (JSOG) has collected cycle\u2010based data for assisted reproductive technology (ART) in an online registry. Here, we present the characteristics and treatment outcomes of ART cycles registered during 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Japanese ART registry consists of cycle\u2010specific information for all ART treatment cycles implemented at 621 participating facilities. We conducted descriptive analyses for such cycles registered for 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 454\u00a0893 treatment cycles and 56\u00a0979 neonates were reported in 2018: both increased from 2017. The mean maternal age was 38.0\u00a0years (standard deviation\u00a0\u00b1\u00a04.7). Of 247\u00a0402 oocyte retrievals, 118\u00a0378 (47.8%) involved freeze\u2010all\u2010embryos cycles; fresh embryo transfer (ET) was performed in 50\u00a0463 cycles: a decreasing trend since 2015. A total of 199\u00a0914 frozen\u2010thawed ET cycles were reported, resulting in 69\u00a0357 pregnancies and 49\u00a0360 neonates born. Single ET (SET) was performed in 82.2% of fresh transfers and 83.4% of frozen\u2010thawed cycles, with singleton pregnancy\/live birth rates of 97.2%\/97.2% and 97.0%\/97.2%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Total ART cycles and subsequent live births increased in 2018. SET was performed in over 80% of cases, and the mode of ET has shifted continuously from using fresh embryos to frozen\u2010thawed ones compared with previous years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12358","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T20:18:19Z","timestamp":1605903499000},"page":"3-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Assisted reproductive technology in Japan: A summary report for 2018 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology"],"prefix":"10.1002","volume":"20","author":[{"given":"Osamu","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-5714","authenticated-orcid":false,"given":"Seung Chik","family":"Jwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-896X","authenticated-orcid":false,"given":"Yukiko","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Toho University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Hamatani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Keio University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"AdamsonGD et al.International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology 2016.2020.https:\/\/secureservercdn.net\/198.71.233.47\/3nz.654.myftpupload.com\/wp\u2010content\/uploads\/ICMART\u2010ESHRE\u2010WR2016\u2010FINAL\u201020200901.pdfAccessed September 13 2020."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12258"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12014"},{"key":"e_1_2_8_5_1","unstructured":"Ministry of Health Labour and Welfare.Summary of vital statistics in 2019 Tokyo.2020.https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/kakutei19\/dl\/02_kek.pdf. Accessed September 13 2020"},{"key":"e_1_2_8_6_1","unstructured":"Ministry of Health Labour and Welfare.Summary of vital statistics in 2018 Tokyo.2019.https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/kakutei18\/dl\/02_kek.pdf. Accessed September 13 2020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513873"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy033"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32843-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703768"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2519"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.039"},{"key":"e_1_2_8_13_1","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari A","year":"2015","journal-title":"Hum Reprod"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803072"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T15:41:34Z","timestamp":1693755694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/rmb2.12358"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12358","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]},"assertion":[{"value":"2020-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}