{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:26:27Z","timestamp":1781177187629,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Previous studies have reported different methods of estrogen administration during endometrial preparation for frozen\u2010thawed embryo transfer (FET). This study aimed to investigate a beneficial regimen of transdermal estrogen administration for FET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the reproductive and obstetric outcomes of FET by comparing the increasing dose (ID) group that mimics changes in serum estradiol during the menstrual cycle and the constant dose (CD) group. Transdermal patches were used for estrogen administration in both groups. In our hospital, we targeted 315 cycles of the ID group in which FET was performed in 2017 and 324 cycles of the CD group in which FET was performed in 2018. In all cases, single embryo transfer was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All were singleton pregnancies. There was no difference in clinical pregnancy rate (28.9% vs 28.2%, <jats:italic>P<\/jats:italic>\u00a0=.837) and live birth rate (17.3% vs 21.4%, <jats:italic>P<\/jats:italic>\u00a0=.201) between the ID and CD groups. Spontaneous abortion rate was significantly lower in the CD group than in the ID group (37.2% vs 23.0%, <jats:italic>P<\/jats:italic>\u00a0=.041). There was no difference in obstetrical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was considered that the simple CD regimen may be more beneficial than the complicated ID regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12370","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T17:08:34Z","timestamp":1613322514000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of transdermal estrogen dose regimen for endometrial preparation of frozen\u2010thawed embryo transfer on reproductive and obstetric outcomes"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-8157","authenticated-orcid":false,"given":"Tatsuyuki","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo Japan"},{"name":"Konohana Clinic Kai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Ogi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa090"},{"key":"e_1_2_8_3_1","unstructured":"ART Registry of Japan.Japan society of obstetrics and gynecology;2018.http:\/\/plaza.umin.ac.jp\/~jsog\u2010art\/2018data_20201001.pdf. Accessed 11 Nov 2020"},{"key":"e_1_2_8_4_1","first-page":"CD003414","article-title":"Cycle regimens for frozen\u2010thawed embryo transfer","volume":"7","author":"Ghobara T","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.16.1.51"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1380-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57730-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198603273141302"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142505"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01132871"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew099"},{"key":"e_1_2_8_12_1","first-page":"378","volume-title":"Towards Reproductive Certainly: Infertility and Genetics Beyond 1999","author":"Gardner DK","year":"1999"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez079"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.04.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1097"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58094-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58504-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.010"},{"key":"e_1_2_8_19_1","first-page":"191","article-title":"Endometrial preparation for women undergoing embryo transfer frozen\u2010thawed embryo transfer with and without pretreatment with gonadotropin releasing hormone agonists","volume":"12","author":"Movahedi S","year":"2018","journal-title":"J Family Reprod Health"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-3044-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez229"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:40:10Z","timestamp":1693568410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,13]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/rmb2.12370"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12370","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,13]]},"assertion":[{"value":"2020-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}