{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:20:42Z","timestamp":1781702442480,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To provide information about the relationship between follow\u2010up period and follicular development in patients with infertility due to premature ovarian insufficiency (POI) who are undergoing hormone replacement therapy (HRT). It is necessary to detect follicle development for artificial insemination or in vitro fertilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted at a university hospital in Tokyo, Japan, from April 2014 to February 2019 in 20 patients [follicular development group, 11 women (55%); non\u2010follicular development group, 9 women (45%)] with POI; their follicular development was followed up weekly. Background characteristics, including age, follicle\u2010stimulating hormone (FSH) and anti\u2010Mullerian hormone levels (AMH), the period from the last spontaneous menstruation to hormone replacement therapy initiation, and follow\u2010up period during HRT were investigated. The period without follicular development was tabulated, and the subsequent cumulative follicular development detection rate was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least 1\u2010year follow\u2010up, the cumulative follicular development rate was 70%; follicular development was observed with a probability of 49.1% at 3\u00a0months, 33.4% at 6\u00a0months, and 8.3% at 12\u00a0months in the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results show that the longer the non\u2010follicle development period, the lower the probability of subsequent follicular development in patients with POI during HRT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12375","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T03:59:26Z","timestamp":1616212766000},"page":"234-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Follicular development during hormone replacement therapy in patients with premature ovarian insufficiency"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-1004","authenticated-orcid":false,"given":"Takuma","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Kusuhara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jikei University School of Medicine Tokyo 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