{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:37:12Z","timestamp":1771328232231,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We investigated the cumulative live birth rate (CLBR) in women receiving governmental subsidies for assisted reproductive technology (ART) in Saitama Prefecture, Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women who applied for subsidies from Saitama Prefectural Government for the first time in 2016 were enrolled and followed up until the end of 2017. Treatment information, including live birth, was obtained from the Japanese ART registry by linking it with unique identification numbers for treatment. Patients\u2019 factors associated with having a live birth were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,072 women (2,513 applications), 495 (46.2%) had a live birth with 8 (1.6%) twin pregnancies. The CLBR over six subsidized cycles was 53.7% for women aged &lt;40\u00a0years, and 17.2% over three subsidized cycles for women 40\u201042\u00a0years; highest among women &lt;35\u00a0years (58.4%), followed by those aged 35\u201039\u00a0years (49.3%). Multivariate analysis revealed patient age as the only independent factor for having a live birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CLBR of women receiving subsidies for ART was greatest in women aged &lt;35\u00a0years. Effective policies for promoting ART among younger couples who seek infertility treatment are essential.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12397","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T17:49:36Z","timestamp":1624211376000},"page":"451-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cumulative live birth rate according to the number of receiving governmental subsidies for assisted reproductive technology in Saitama Prefecture, Japan: A retrospective study using individual data for governmental subsidies"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-5714","authenticated-orcid":false,"given":"Seung Chik","family":"Jwa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Reproductive Medicine Graduate School Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Saito","sequence":"additional","affiliation":[{"name":"Umegaoka Women's Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Public Health Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Science and Public Health Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12358"},{"key":"e_1_2_11_3_1","unstructured":"Ministry of Health Labour and Welfare.Summary of vital statistics in 2018 (In Japanese). Tokyo.2019.https:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/kakutei18\/dl\/02_kek.pdfAccessed: 13\/Sep\/2020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi006"},{"key":"e_1_2_11_5_1","unstructured":"Cabinet Office.Declining Birthrate White Paper (In Japanese). Tokyo. 2020.https:\/\/www8.cao.go.jp\/shoushi\/shoushika\/whitepaper\/measures\/w\u20102020\/r02pdfhonpen\/r02honpen.htmlAccessed: 17\/Jan\/2021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa090"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60828-3"},{"key":"e_1_2_11_8_1","unstructured":"Ministry of Health Labour and Welfare.Enlargement of subsidies for assisted reproductive technology (In Japanese). Tokyo. 2020.https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000047270.html. Accessed: 17\/Jan\/2021."},{"key":"e_1_2_11_9_1","unstructured":"Working group for appropriate governmental subsidies for infertility patients.Report of appropriate governmental subsidies for infertility patients (In Japanese). 2013.https:\/\/www.mhlw.go.jp\/file\/04\u2010Houdouhappyou\u201011908000\u2010Koyoukintoujidoukateikyoku\u2010Boshihokenka\/0000016937.pdfAccessed: 17\/Jan\/2021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh221"},{"key":"e_1_2_11_11_1","unstructured":"AdamsonGD et al.International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology 2016. 2020.https:\/\/secureservercdn.net\/198.71.233.206\/3nz.654.myftpupload.com\/wp\u2010content\/uploads\/ICMART\u2010ESHRE\u2010WR2016\u2010FINAL\u201020200901.pdfAccessed: 13\/Sep\/2020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12307"},{"issue":"337","key":"e_1_2_11_14_1","first-page":"e3","article-title":"Impact of single embryo transfer policy on perinatal outcomes in fresh and frozen cycles\u2010analysis of the Japanese Assisted Reproduction Technology registry between 2007 and 2012","volume":"105","author":"Takeshima K","year":"2016","journal-title":"Fertil Steril"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.1405"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.04.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1357"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001338"},{"key":"e_1_2_11_20_1","first-page":"219","article-title":"Effect of publicly funded assisted reproductive technology on maternal and infant outcomes: a pre\u2010 and post\u2010comparison study","volume":"36","author":"Wei SQ","year":"2021","journal-title":"Hum Reprod"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det405"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.10.007"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu067"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa030"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.043"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5735"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1213687"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:41:07Z","timestamp":1693312867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,20]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/rmb2.12397"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12397","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,20]]},"assertion":[{"value":"2021-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}