{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:37:02Z","timestamp":1787315822774,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Japan Society of Obstetrics and Gynecology records online annual cycle\u2010based information for assisted reproductive technology (ART). This report presents the characteristics and treatment outcomes of ART cycles registered during 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Japanese ART registry includes cycle\u2010specific information from 619 participating facilities, including treatment and pregnancy outcomes. Descriptive analyses were conducted for cycles registered during 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2019, 458\u00a0101 treatment cycles and 60\u00a0598 neonates were reported, both of which increased from 2018. The number of fresh cycles, including in vitro fertilization and intracytoplasmic sperm injection, decreased, while frozen\u2010thawed embryo transfer (ET) cycles increased. The mean maternal age was 37.9\u00a0years (standard deviation\u00a0\u00b1\u00a04.7). Of 239\u00a0348 oocyte retrievals, 123\u00a0690 (51.7%) involved freeze\u2010all\u2010embryos cycles; fresh ET was performed in 41\u00a0831 cycles (a decreasing trend since 2015). In 2019, there were 211\u00a0597 frozen\u2010thawed ET cycles, resulting in 74\u00a0882 pregnancies and 54\u00a0168 neonates born. Single ET was performed in 82.6% of fresh transfers and 85.1% of frozen\u2010thawed cycles, with singleton live birth rates of 97.3% for both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The number of fresh cycles decreased but frozen cycles increased in 2019. Single ET was performed in &gt;80% of cases, and the proportion of babies born from frozen\u2010thawed ET increased.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12434","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T06:15:26Z","timestamp":1639462526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Assisted reproductive technology in Japan: A summary report for 2019 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-896X","authenticated-orcid":false,"given":"Yukiko","family":"Katagiri","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Toho University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-5714","authenticated-orcid":false,"given":"Seung Chik","family":"Jwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Saitama Medical University  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-5687","authenticated-orcid":false,"given":"Takeshi","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Graduate School of Biomedical Sciences Tokushima University  Tokushima 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