{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:24:49Z","timestamp":1792095889001,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endometriosis is an estrogen\u2010dependent disease and causes pelvic pain and infertility. The limits of current pharmacotherapy in women who desire to become pregnant prompt the development of various targeted molecules for more effective treatment. A review article focused on the unique aspect of cellular metabolic reprogramming of endometriotic cells has been reported. The cellular metabolic pathways are reprogrammed to adapt to a variety of environmental stresses (e.g., nutrient starvation or glucose deprivation, hypoxic stress, excessive reactive oxygen species generation, and other environmental factors). This review aims to summarize macrophage polarization and metabolic reprogramming in endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed between January 2000 and March 2022 in the PubMed and Google Scholar databases using a combination of specific terms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macrophage cellular metabolism has a marked influence on its phenotype and function. Preclinical studies showed that metabolic conversion toward glycolysis or oxidative phosphorylation drives macrophage polarization to M1 or M2 phenotype, respectively. Such cellular metabolic rewiring can offer new therapeutic opportunities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A better understanding of metabolic reprogramming biology in endometriosis\u2010associated macrophages is essential in considering novel therapeutic approach for endometriosis. However, there are currently no detailed studies on therapeutic strategies targeting the cellular metabolic properties of endometriosis\u2010associated macrophages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12488","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T15:19:15Z","timestamp":1666019955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-6269","authenticated-orcid":false,"given":"Hiroshi","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Gynecology Ms.Clinic MayOne  Kashihara, Nara Japan"},{"name":"Department of Obstetrics and Gynecology Nara Medical University  Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Imanaka","sequence":"additional","affiliation":[{"name":"Department of Gynecology Ms.Clinic MayOne  Kashihara, Nara Japan"},{"name":"Department of Obstetrics and Gynecology Nara Medical University  Kashihara, Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.041"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897211002762"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP\u201017\u20100342"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12330"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916144116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/RAF\u201021\u20100053"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.12.044"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101546\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01462"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaw045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20101026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118789513"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13139"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.414"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.01.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14135"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab266"},{"key":"e_1_2_9_21_1","first-page":"194","article-title":"The M2 polarization of macrophage induced by fractalkine in the endometriotic milieu enhances invasiveness of endometrial stromal cells","volume":"7","author":"Wang Y","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010022\u201000890\u20106"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.08.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.04.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1409717"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6285813"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12331"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201057207\u2010y"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003056\u2010x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015\u20100282(97)81439\u20102"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158134"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del516"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.05.066"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.11.2528"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw006"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2003.01207.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den375"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010017\u20100828\u20103"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00108"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100897.2010.00887.x"},{"key":"e_1_2_9_45_1","first-page":"303","article-title":"Alternative activation of macrophages in rhesus macaques (Macaca mulatta) with endometriosis","volume":"62","author":"Smith KA","year":"2012","journal-title":"Comp Med"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.656145"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20107866"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox118"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010021\u201000770\u20109"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac081"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.09.019"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12276"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.118604"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.522037"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.005"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9029327"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32529"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz113"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S323790"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2014.969421"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmb2.12488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:22:02Z","timestamp":1692483722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/rmb2.12488"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12488","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12488"}}