{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:00:10Z","timestamp":1773021610748,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the short\u2010term efficacy and safety of a combined mifepristone\u2010misoprostol regimen in individuals seeking medical abortion at up to 63\u2009days of gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This open\u2010label, multicenter, prospective study evaluated the short\u2010term efficacy and safety of medical abortion, with the primary outcome being the abortion success rate 24\u2009h after misoprostol administration. The participants received 200\u2009mg of mifepristone orally and 800\u2009\u03bcg of misoprostol buccally in the hospital\/clinic 36\u201348\u2009h later. Bleeding and lower abdominal pain, which are the main symptoms associated with medical abortion, were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The abortion success rate was 93.3% (95% confidence interval [CI]: 87.3\u201397.1%) within 24\u2009h of misoprostol administration, 63.3% (95% CI: 54.05\u201371.94%) within 4\u00a0h, and 90.0% (95% CI: 83.18\u201394.73%) within 8\u00a0h. The median time from misoprostol administration to a successful abortion was 3.93\u2009h. Bleeding was most commonly observed 0\u20134\u00a0h prior to the confirmation of gestational sac (GS) expulsion. The most intense lower abdominal pain occurred 0\u20131\u00a0h before the confirmation of GS expulsion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combined regimen of mifepristone and buccal misoprostol for medical abortion showed short\u2010term efficacy and a favorable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12512","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T06:45:36Z","timestamp":1680331536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Short\u2010term efficacy and safety of early medical abortion in Japan: A multicenter prospective study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-1066","authenticated-orcid":false,"given":"Yutaka","family":"Osuga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine The 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