{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:28Z","timestamp":1787761948307,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We evaluated factors affecting the development of endometrial receptivity according to age and changes in the endometrial microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited patients with infertility who underwent transcriptomic analyses of endometrial receptivity and the endometrial microbiome prior to frozen embryo transfer. An endometrial biopsy was performed 108\u2009h after initial progesterone administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 185 tests from 185 eligible patients, the results of endometrial receptivity analysis were receptive in 111 (60.0%) patients and pre\u2010receptive in 74 (40.0%) patients. Compared with receptive patients, pre\u2010receptive patients had significantly older ages (36.0\u2009\u00b1\u20090.5 vs. 38.2\u2009\u00b1\u20090.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.0021), a smaller proportion of normal <jats:italic>Lactobacillus<\/jats:italic>\u2010dominant microbiota (27.9% vs. 12.2%), and a greater proportion of microbiota with ultralow biomass (22.5% vs. 41.9%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0074). Patient age (adjusted odds ratio: 1.08, 95% confidence interval: 1.01\u20131.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.0351) and a microbiome with ultralow biomass (adjusted odds ratio: 3.82, 95% confidence interval: 1.49\u20139.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.0039) were independent predictive factors for pre\u2010receptive endometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older age was accompanied by a decrease in <jats:italic>Lactobacillus<\/jats:italic>\u2010dominant microbiota; aging and endometrial microbiota with ultralow biomass were significantly associated with pre\u2010receptive endometrium. Our findings suggest that the quantity (rather than proportion) of <jats:italic>Lactobacillus<\/jats:italic> in the endometrium is important in the development of endometrial receptivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12523","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T17:01:46Z","timestamp":1687885306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Age\u2010 and endometrial microbiota\u2010related delay in development of endometrial receptivity"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-1052","authenticated-orcid":false,"given":"Shunsaku","family":"Fujii","sequence":"first","affiliation":[{"name":"ef.clinic  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Oguchi","sequence":"additional","affiliation":[{"name":"ef.clinic  Aomori 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