{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:18:22Z","timestamp":1791346702681,"version":"4.3.1"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08865"],"award-info":[{"award-number":["23K08865"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary ovarian insufficiency (POI) is characterized by the development of hypergonadotropic hypogonadism before 40\u2009years of age and leads to intractable infertility. Although in\u00a0vitro fertilization and embryo transfer with donated eggs enables pregnancy, not a few patients desire pregnancy using their oocytes. However, follicular development is rare and unpredictable in patients with POI. Thus, there is a need for treatments that promote the development of residual follicles and methods to accurately predict infrequent ovulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review discusses the effects of various treatments for obtaining eggs from POI patients. Furthermore, this study focused a potential marker for predicting follicular growth in patients with POI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Findings<\/jats:title><jats:p>Different treatments such as hormone\u2010replacement therapy, dehydroepiandrosterone supplementation, platelet\u2010rich plasma injection, and in\u00a0vitro activation have shown varying degrees of effectiveness in retrieving oocytes from patients with POI. To predict follicle development in the cycle, elevated serum estradiol and reduced follicle\u2010stimulating hormone (FSH) levels are important. However, these markers are not always reliable under continuous estradiol\u2010replacement therapy. As a novel marker for predicting follicle growth, serum anti\u2010M\u00fcllerian hormone (AMH) levels, measured using the picoAMH enzyme\u2010linked immunosorbent assay, were found to predict follicle growth in patients and the cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review highlights the challenges and available interventions for achieving pregnancy using a patient's oocytes in cases of POI. We believe that a combination of currently available treatments and prediction methods is the best strategy to enable patients with POI to conceive using their own eggs. Although AMH levels may predict follicle growth, further research is necessary to improve the chances of successful follicular development and conception in patients with POI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12556","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T06:48:54Z","timestamp":1703314134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-7982","authenticated-orcid":false,"given":"Satoko","family":"Osuka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Tokoname City Hospital  Tokoname\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Iyoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Institute for Advanced Research Nagoya University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Sonehara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Myake","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Muraoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Division of Perinatology, Center for Maternal\u2010Neonatal Care Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Division of Perinatology, Center for Maternal\u2010Neonatal Care Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-884X","authenticated-orcid":false,"given":"Akira","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808697"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3960"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2019.1574738"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"235","article-title":"Primary ovarian insufficiency: an update","volume":"6","author":"Cox L","year":"2014","journal-title":"Int J Womens Health"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0637-9430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003477"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex027"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.2678"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.5888"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1874-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9786-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12453"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14073"},{"issue":"11","key":"e_1_2_7_16_1","first-page":"2051","article-title":"Fertility preservation in female oncology patients: the influence of the type of cancer on ovarian stimulation response","volume":"33","author":"Alvarez RM","year":"2018","journal-title":"Hum Reprod"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.12.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1319"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.855992"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00483-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103403"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061809"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1152-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3071"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0882-3791"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312830110"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ14-0189"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)60785-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.08.086"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13633"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115618284"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.2.483"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.9.2268"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20104"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05834-x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0297-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz6830"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.09.006"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hox007"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-00896-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0599"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.032"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.5.483"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57722-X"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.028"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0713-5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2016.01.002"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207325666220820164357"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.653857"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2011.02.1861"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10030303"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2144177"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1159-8"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02385-w"},{"issue":"12","key":"e_1_2_7_55_1","article-title":"A systematic review evaluating the efficacy of intra\u2010ovarian infusion of autologous platelet\u2010rich plasma in patients with poor ovarian reserve or ovarian insufficiency","volume":"12","author":"Panda SR","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu353"},{"issue":"5","key":"e_1_2_7_57_1","first-page":"1470","article-title":"Development of luteinized graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure","volume":"79","author":"Nelson LM","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"e_1_2_7_58_1","first-page":"3615","article-title":"A randomized, controlled trial of estradiol replacement therapy in women with hypergonadotropic amenorrhea","volume":"81","author":"Taylor AE","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12375"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.127"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.042"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.023"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.05.042"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn001"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.601752"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu020"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.224"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1114078"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-015-0227-3"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0210-9"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9880-1"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac045"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac004"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14458"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02607"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.04.004"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.02.105"},{"issue":"1","key":"e_1_2_7_78_1","first-page":"1","article-title":"Back to the basics of ovarian aging: a population\u2010based study on longitudinal anti\u2010M\u00fcllerian hormone decline","volume":"14","author":"Kat AC","year":"2016","journal-title":"BMC Med"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.06.018"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.046"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu036"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.719029"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00603"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.06.011"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.05.014"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00278-4"},{"key":"e_1_2_7_87_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plabm.2019.e00140","article-title":"Validation of the picoAMH assay on the Dynex DS2 platform","volume":"17","author":"Garnett ER","year":"2019","journal-title":"Pract Lab Med"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T17:24:54Z","timestamp":1708622694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/rmb2.12556"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12556","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12556"}}