{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:20:57Z","timestamp":1767183657724,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to elucidate the factors that affect the dynamics of blood D\u2010dimer in ovarian hyperstimulation syndrome (OHSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical records from two hospitals and extracted data obtained during assisted reproductive technology and OHSS treatment. Blood D\u2010dimer levels during hospitalization were plotted against body weight. Other factors possibly related to blood D\u2010dimer levels were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 10 patients with OHSS admitted between January 2013 and June 2023. In all patients, blood D\u2010dimer levels increased significantly when they convalesced from OHSS and lost weight. None of the patients showed clinical signs of thrombosis, which was confirmed using imaging tests in 8 of 10 patients. Two patients underwent cell\u2010free and concentrated ascites reinfusion therapy (CART), and their blood D\u2010dimer levels increased dramatically after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Weight change and CART are associated with blood D\u2010dimer dynamics in OHSS. Our results show that elevated blood D\u2010dimer levels in patients with OHSS do not always represent the presence of thrombosis. Reinfusion of pooled D\u2010dimer in ascites may explain the D\u2010dimer surge during the recovery phase or after CART in these patients. Our study provides new perspectives on the clinical implications of D\u2010dimer during OHSS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12563","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T05:16:01Z","timestamp":1707974161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reinfusion of peritoneal fluid elevates the level of plasma D\u2010dimer in patients with <scp>early\u2010onset<\/scp> ovarian hyperstimulation syndrome"],"prefix":"10.1002","volume":"23","author":[{"given":"Shiori","family":"Kumazawa","sequence":"first","affiliation":[{"name":"Department of Comprehensive Reproductive Medicine, Graduate School Tokyo Medical and Dental University  Tokyo 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