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We aimed to evaluate penile blood flow in\u00a0vivo and analyze its possible relationship with the lymphatic maker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We established an in\u00a0vivo system designed to assess the dynamic blood outflow from the corpus cavernosum (CC) by dye injection. To analyze lymphatic characteristics in the CC, the expression of Lyve\u20101, the key lymphatic endothelium marker, was examined by the in\u00a0vitro system and lipopolysaccharide (LPS) injection to mimic the inflammatory conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A novel cavernography methods enable high\u2010resolution morphological and functional blood drainage analysis. The expression of Lyve\u20101 was detected along the sinusoids. Furthermore, its prominent expression was also observed after penile LPS injection and in the erectile condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current in\u00a0vivo system will potentially contribute to the assessment of penile pathology from a novel viewpoint. In addition, current analyses revealed inducible Lyve\u20101 expression for LPS injection and the erection state, which requires further analyses on penile lymphatic system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12570","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T05:15:06Z","timestamp":1712034906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel erectile analyses revealed augmentable penile Lyve\u20101, the lymphatic marker, expression"],"prefix":"10.1002","volume":"23","author":[{"given":"Kota","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics, Institute of Advanced Medicine Wakayama Medical University  Wakayama Japan"},{"name":"Department of Plastic and Reconstructive Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Institute of Advanced Medicine Wakayama Medical University  Wakayama Japan"},{"name":"Department of Physiology and Regenerative Medicine, Faculty of Medicine Kindai University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Science Institute Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kumegawa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Asamura","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-2660","authenticated-orcid":false,"given":"Gen","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Developmental Genetics, Institute of Advanced Medicine Wakayama Medical University  Wakayama Japan"},{"name":"Department of Plastic and Reconstructive Surgery Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-019-0224-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.01.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01845-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2021.06.009"},{"key":"e_1_2_8_6_1","unstructured":"PanchatsharamPK DurlandJ ZitoPM.Physiology erection. 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