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The lncRNAs that were upregulated and downregulated in HGSC in comparison to multiple samples of normal ovary and fallopian tube were validated by real\u2010time RT\u2010PCR. To infer the function, ovarian cancer cell lines that overexpress the identified lncRNAs were established, and the activation of cell proliferation, migration, and invasion was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven lncRNAs (ACTA2\u2010AS1, ADAMTS9\u2010AS2, CBR3\u2010AS1, HAND2\u2010AS1, IPW, LINC00312, LINC00887, MEG3, NBR2, TSIX, and XIST) were downregulated in HGSC samples. We established the cell lines that overexpress ADAMTS9\u2010AS2, CBR3\u2010AS1, or NBR2. In cell lines overexpressing ADAMTS9\u2010AS2, cell proliferation was suppressed, but migration and invasion were promoted. In cell lines overexpressing CBR3\u2010AS1 or NBR2, cell migration tended to be promoted, although cell proliferation and invasion were unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified eleven lncRNAs that were specifically downregulated in HGSC. Of these, CBR3\u2010AS1, NBR2, and ADAMTS9\u2010AS2 had unique functions in the malignant behaviors of HGSC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12572","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T11:24:22Z","timestamp":1712143462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identification of long noncoding RNAs downregulated specifically in ovarian high\u2010grade serous carcinoma"],"prefix":"10.1002","volume":"23","author":[{"given":"Maki","family":"Hayashi\u2010Okada","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-7716","authenticated-orcid":false,"given":"Shun","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Tamehisa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kajimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-5556","authenticated-orcid":false,"given":"Isao","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Sueoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8874-7931","authenticated-orcid":false,"given":"Norihiro","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf3d79"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030527"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3192"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109810"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.04.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01002-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.12.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031079"},{"key":"e_1_2_10_13_1","first-page":"277","article-title":"Identification of aberrantly expressed long non\u2010coding RNAs in ovarian high\u2010grade serous carcinoma cells. 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