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We performed a random\u2010effects meta\u2010analysis to compare the efficacy and safety of follitropin \u03b4 and follitropin \u03b1\/\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched randomized controlled trials comparing follitropin \u03b4 and follitropin \u03b1\/\u03b2 using MEDLINE, Embase, CENTRAL, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, and WHO\u2010ITCRP on December 14, 2022. The primary outcomes were the live birth rate and the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS). The certainty of the evidence was assessed using the grading of recommendations assessment, development, and evaluation approach. The protocol was registered on the Open Science Framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three studies involving 2682 participants were included in our meta\u2010analysis. The results indicated that follitropin \u03b4 may result in little to no difference in live birth rates (risk ratio [RR], 1.12; 95% confidence interval [CI], 0.91\u20131.38; low certainty) and the incidence of moderate or severe OHSS (RR, 0.78; 95% CI, 0.48\u20131.26; low certainty) compared with follitropin \u03b1\/\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Follitropin \u03b4 may result in little to no difference in COS compared with follitropin \u03b1\/\u03b2, especially in terms of live births and safety.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12573","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T09:15:51Z","timestamp":1711358151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of follitropin delta versus follitropin alpha\/beta in infertility treatment: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-7809","authenticated-orcid":false,"given":"Shinnosuke","family":"Komiya","sequence":"first","affiliation":[{"name":"HORAC Grand Front Osaka Clinic  Osaka Japan"},{"name":"Department of Obstetrics and Gynecology Kansai Medical University Graduate School of Medicine  Hirakata, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG)  Osaka Japan"},{"name":"Division of Gastroenterological, General and Transplant Surgery, Department of Surgery Jichi Medical University  Shimotsuke Japan"},{"name":"Division of Community and Family Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takero","family":"Terayama","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG)  Osaka Japan"},{"name":"Division of Traumatology and Critical Care Medicine National Defense Medical College  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7375-7651","authenticated-orcid":false,"given":"Kyosuke","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Systematic Review Workshop Peer Support Group (SRWS\u2010PSG)  Osaka Japan"},{"name":"Division of Gynecology Nagano Municipal Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7932-6999","authenticated-orcid":false,"given":"Hidetaka","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kansai Medical University Graduate School of Medicine  Hirakata, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001750.pub4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010537.pub5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012103.pub2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1592153"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC\u201017\u20100067"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex219"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.112"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME\u201017\u20100308"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00429"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.06.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab155"},{"key":"e_1_2_7_14_1","unstructured":"ClinicalTrials.gov [Internet].Efficacy and safety of FE999049 in controlled ovarian stimulation in Pan\u2010Asian women.2023[cited 2024 Feb 1]. 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