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This review seeks to clarify evidence\u2010based testing and treatments for implantation failure after euploid embryo transfer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a review of the literature on implantation failure after euploid embryo transfer or multiple embryo transfer cycles, which mainly included systematic reviews and meta\u2010analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recommended tests for implantation failure include (1) hysteroscopy, (2) endometrial CD138 immunohistochemistry and bacterial culture, (3) serum 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub>, and (4) thrombophilia screening. Based on diagnostic findings, the following treatments have been recommended: (1) antibiotics for chronic endometritis, (2) vitamin D replacement, (3) lifestyle modification, and (4) low\u2010dose aspirin starting from the postimplantation period for thrombophilia. Moreover, frozen\u2013thawed single euploid blastocyst transfer using assisted hatching and hyaluronan\u2010enriched transfer medium may support embryo implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To ensure a successful pregnancy in subsequent embryo transfers, simple, inexpensive, and evidence\u2010based tests and treatments should be selected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12576","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:44:49Z","timestamp":1712580289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management strategies following implantation failure of euploid embryos"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-9159","authenticated-orcid":false,"given":"Keiji","family":"Kuroda","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine and 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