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Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding of implantation remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This paper provides a comprehensive review of the current research on lipids in the context of early pregnancy, with a particular focus on feto\u2010maternal communications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Findings<\/jats:title><jats:p>Embryo implantation entails direct interaction between uterine tissues and embryos. Introducing embryos triggers significant changes in uterine epithelial morphology and stromal differentiation, facilitating embryo implantation through communication with uterine tissue. Studies employing genetic models and chemical compounds targeting enzymes and receptors have elucidated the crucial roles of lipid mediators\u2014prostaglandins, lysophosphatidic acid, sphingosine\u20101\u2010phosphate, and cannabinoids\u2014in early pregnancy events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the high conservation of lipid synthases and receptors across species, lipid mediators likely play pivotal roles in rodents and humans. 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