{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:21:15Z","timestamp":1791969675098,"version":"4.3.4"},"reference-count":167,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased oxidative stress (OS), resulting from the delicate balance between reactive oxygen species (ROS) production and antioxidant defense, is closely linked to sperm abnormalities and male subfertility. Elevated ROS levels particularly affect sperm quality. The vulnerability of spermatozoa to ROS is due to the absence of DNA repair mechanisms and the high presence of polyunsaturated fatty acids in their membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This article updates and advances our understanding of the molecular damage caused by OS in spermatozoa, including lipid peroxidation, DNA damage, motility, and functionality. Additionally, the review discusses the challenges in diagnosing OS in semen and recommends accurate and sensitive testing methods. Case studies are utilized to demonstrate the effective management of male infertility caused by OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main findings<\/jats:title><jats:p>Highlighting the need to bridge the gap between research and clinical practice, this review suggests strategies for clinicians, such as lifestyle and dietary changes and antioxidant therapies. The review emphasizes lifestyle modifications and personalized care as effective strategies in managing male infertility caused by OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review calls for early detection and intervention and interdisciplinary collaboration to improve patient care in male infertility cases related to increased OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12598","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T03:49:14Z","timestamp":1725248954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Oxidative stress affects sperm health and fertility\u2014Time to apply facts learned at the bench to help the patient: Lessons for busy clinicians"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-5048","authenticated-orcid":false,"given":"Pallav","family":"Sengupta","sequence":"first","affiliation":[{"name":"Global Andrology Forum  Moreland Hills Ohio USA"},{"name":"Department of Biomedical Sciences, College of Medicine Gulf Medical University  Ajman UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-2494","authenticated-orcid":false,"given":"Germar\u2010M.","family":"Pinggera","sequence":"additional","affiliation":[{"name":"Global Andrology Forum  Moreland Hills Ohio USA"},{"name":"Department of Urology Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-335X","authenticated-orcid":false,"given":"Aldo E.","family":"Calogero","sequence":"additional","affiliation":[{"name":"Global Andrology Forum  Moreland Hills Ohio USA"},{"name":"Division of Endocrinology, Metabolic Diseases and Nutrition University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-1026","authenticated-orcid":false,"given":"Ashok","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Global Andrology Forum  Moreland Hills Ohio USA"},{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22764"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.77"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12778"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2017.10.007"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.230232"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.220282"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-32300-4_6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939\u20104640.2002.tb02324.x"},{"issue":"4","key":"e_1_2_13_10_1","first-page":"357","article-title":"Oxidative stress & male infertility","volume":"129","author":"Makker K","year":"2009","journal-title":"Indian J Med Res"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0117"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.166"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD15325"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2014.32.1.1"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2019.1599624"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2008.07.052"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.12.004"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13012"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2017.1422046"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v17i2.16"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2012.710631"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(02)04948\u20108"},{"issue":"3","key":"e_1_2_13_23_1","first-page":"44","article-title":"Reactive oxygen species in human sperm suspensions: production by leukocytes and the generation of NADPH to protect sperm against their effects","volume":"20","author":"Ford WC","year":"1997","journal-title":"Int J Androl"},{"key":"e_1_2_13_24_1","first-page":"7","volume-title":"Laboratory manual for the examination and processing of human semen","author":"Press W","year":"2010"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u201012\u201045"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102795(199708)47:4<468::AID\u2010MRD14>3.0.CO;2\u2010S"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u201010\u201092"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019208987691"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010014\u20100425\u20107"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.01.008"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802144422"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/014850100262326"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012453790-3\/50030-5"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472\u20106483(10)61190\u2010X"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682X.170441"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.002"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100897.2007.00559.x"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010005\u20101097\u20105"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.04.002"},{"issue":"4","key":"e_1_2_13_40_1","first-page":"239","article-title":"Morphological diversity of sperm: a mini review","volume":"12","author":"Prakash S","year":"2014","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.14.4.231"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11051002"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.001"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.21037\/amj.2018.01.06"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.002"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-37972-8_9"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.014"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12762"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200128"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383\u20105718(01)00300\u2010X"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2014.08.006"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071025"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020134"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2022.08.018"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2014.05.003"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1614916"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231188655"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.09.006"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010020\u201000334\u2010z"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.21451\/1984\u20103143\u2010ar2019\u20100062"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8213071"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD17533"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072\u2010018\u20100224\u2010y"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199420000660"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071131"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071154"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2016.00067"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2016.1177743"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11093554"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22604"},{"issue":"1","key":"e_1_2_13_71_1","first-page":"37","article-title":"Effects of dietary magnesium on testicular histology, steroidogenesis, spermatogenesis and oxidative stress markers in adult rats","volume":"51","author":"Chandra AK","year":"2013","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2008.10.002"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010011\u20101217\u20103"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2022.106922"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9090269"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071079"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1530\/RAF\u201020\u20100062"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45020083"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104\u2010023\u201000836\u20101"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep\u201013\u20100313"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010018\u20100358\u20106"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12353"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0810459"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.06.026"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102042.2008.02213.x"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12052"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190055"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.173933"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010015\u20100466\u20106"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.182822"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.029"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396360701883274"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.107.003046"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.4103\/iju.iju_9_17"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9950659"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109343(00)00412\u20105"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0816"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.013"},{"key":"e_1_2_13_100_1","volume-title":"WHO laboratory manual for the examination and processing of human semen","author":"World Health Organization","year":"2021"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25075"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287216652779"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010016\u20100677\u20105"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10030236"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.936"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.10.008"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001521"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010022\u201001741\u20106"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2007.10.004"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716\u201097602011000200009"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/oxygen2010001"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190145"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2020.04175"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19124097"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8040089"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010167"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13644"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89340-8_9"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9030219"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12191"},{"issue":"1","key":"e_1_2_13_121_1","first-page":"383","article-title":"Effect of L\u2010carnitine and\/or L\u2010acetyl\u2010carnitine in nutrition treatment for male infertility: a systematic review","volume":"16","author":"Zhou X","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100272.1994.tb00780.x"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13267"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.18714"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18224"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.26873\/SVR\u20101673\u20102023"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.22074\/ijfs.2021.6236"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2020.04084"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200196"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20104755\u20108\u201024"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12957"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088956"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.148076"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew288"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des298"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv059"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874255601103010105"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.150847"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2011.10503.x"},{"issue":"3","key":"e_1_2_13_140_1","first-page":"201","article-title":"Effects of nicotine on sperm characteristics and fertility profile in adult male rats: a possible role of cessation","volume":"12","author":"Oyeyipo IP","year":"2011","journal-title":"J Reprod Infertil"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.12.003"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377\u20104929.59180"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010018\u20100320\u20107"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq007"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010015\u20100553\u20108"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.173938"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12268"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.175779"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12610\u2010017\u20100060\u20100"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.002"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.220213"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003253\u20108"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.210025"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz103"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.07.024"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9589345"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2020.1824080"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13711"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010017\u20100912\u20108"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep\u201019\u20100452"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.62110\/sciencein.jist.2024.v12.753"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2022.822257"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.76"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682x.122203"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13356"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12914"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102605.2008.00941.x"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1070692"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmb2.12598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T14:41:50Z","timestamp":1736174510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmb2.12598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":167,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/rmb2.12598"],"URL":"https:\/\/doi.org\/10.1002\/rmb2.12598","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12598"}}