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The activating and inhibitory receptors expressed on their surface mediate various functions of uNK cells, such as cytotoxicity, cytokine production, spiral artery remodeling, and self\u2010recognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study reviewed the most recent information (PubMed database, 175 articles included) regarding the activating and inhibitory receptors on uNK cells in human females with healthy pregnancies and the evidence indicating their significance in various reproductive failures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Findings<\/jats:title>\n                    <jats:p>Numerous studies have indicated that the natural cytotoxic receptors, killer cell immunoglobulin\u2010like receptors, and C\u2010type lectin receptors, particularly those expressed on uNK cells, play crucial roles in successful pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As studies on human uNK cells are limited owing to the low availability of fertile samples, and the extrapolation of animal models has certain limitations, the in\u00a0vivo role of uNK cells has not yet been fully elucidated. However, immunotherapies focusing on modulating uNK cell function have been controversial in terms of pregnancy outcomes. Further research is required to elucidate the role of uNK cells in reproduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12610","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T03:39:48Z","timestamp":1736739588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of\n                    <scp>NKp46<\/scp>\n                    and other activating inhibitory receptors on uterine endometrial\n                    <scp>NK<\/scp>\n                    cells in females with various reproductive failures: A review"],"prefix":"10.1002","volume":"24","author":[{"given":"Chuxian","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University  Nishinomiya Hyogo Japan"},{"name":"Reproductive Medicine Centre, Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-7458","authenticated-orcid":false,"given":"Atsushi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University  Nishinomiya Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University  Nishinomiya Hyogo 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