{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:46:04Z","timestamp":1789875964443,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":315,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014475","name":"Pfizer Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) significantly affects women. This study investigated the association between serum anti\u2010M\u00fcllerian hormone (AMH) levels and menstrual cycle disorders, and AMH for PCOS in a general cohort of young Japanese women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured serum AMH levels in 528 healthy female students at two universities in Japan between 2014 and 2020. We investigated the association between serum AMH levels and hormone levels, menstrual cycle, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean (\u00b1standard deviation) AMH level was 4.78\u2009\u00b1\u20092.88\u2009ng\/mL. Correlations were observed between serum AMH and luteinizing hormone (LH) or LH\/follicle\u2010stimulating hormone (FSH) levels in women with irregular menstruation (LH: <jats:italic>r<\/jats:italic>\u2009=\u20090.542, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; LH\/FSH: <jats:italic>r<\/jats:italic>\u2009=\u20090.584, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The optimal serum AMH cutoff value that predicted LH \u22657.1\u2009IU\/L and LH\/FSH \u22651.21 (PCOS diagnostic criteria revised by Japan Society of Obstetrics and Gynecology) in women with menstrual irregularities was 5.30\u2009ng\/mL (area under the curve: 0.815, sensitivity: 84.2%, specificity: 70.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum AMH can be measured during annual health checkups and may be a useful biomarker for early and arcuate diagnosis and intervention in women with PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmb2.12615","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T12:02:45Z","timestamp":1731326565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between anti\u2010M\u00fcllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-4798","authenticated-orcid":false,"given":"Natsuki","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-7982","authenticated-orcid":false,"given":"Satoko","family":"Osuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Health Service Center Aichi Gakuin University  Nisshin Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tonoike","sequence":"additional","affiliation":[{"name":"Health Service Center Aichi Gakuin University  Nisshin Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Uno","sequence":"additional","affiliation":[{"name":"Health Service Center Aichi Gakuin University  Nisshin Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"School of Human Care Studies Nagoya University of Arts and Sciences  Nisshin Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Bayasula","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Sonehara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya 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