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Additionally, NR5A1\u2010positive cells in these tissues exhibit developmental and functional heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This review summarizes recent knowledge on the relationships between physiological functions and gene cascades regulated by NR5A1 in each tissue. In addition, we also present several intriguing examples of disparities in\n                      <jats:italic>Nr5a1<\/jats:italic>\n                      gene regulation within the same tissues, which are relevant to developmentally and functionally heterogeneous cell populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Findings<\/jats:title>\n                    <jats:p>\n                      The adrenal cortex and testicular Leydig cells exhibit clear biphasic developmental processes, resulting in functionally distinct fetal and adult cell populations in which\n                      <jats:italic>Nr5a1<\/jats:italic>\n                      is regulated by distinct enhancers. Similar heterogeneity of cell populations has been suggested in other tissues. However, functional differences in each cell population remain unclear, and\n                      <jats:italic>Nr5a1<\/jats:italic>\n                      gene regulation disparities have not been reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Some steroidogenic tissues demonstrate biphasic development, with fetal and adult cell populations playing distinct and crucial physiological roles.\n                      <jats:italic>Nr5a1<\/jats:italic>\n                      regulation varies across cell populations, and analyses of gene cascades centered on NR5A1 will aid in understanding the mechanisms underlying the development and maturation of reproductive capabilities.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmb2.12621","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:56:37Z","timestamp":1739840197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>NR5A1<\/scp>\n                    and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3581-9852","authenticated-orcid":false,"given":"Miki","family":"Inoue","sequence":"first","affiliation":[{"name":"Division of Microscopic and Developmental Anatomy, Department of Anatomy Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-6405","authenticated-orcid":false,"given":"Kanako","family":"Miyabayashi","sequence":"additional","affiliation":[{"name":"Division of Microscopic and Developmental Anatomy, Department of Anatomy Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0281-8602","authenticated-orcid":false,"given":"Yuichi","family":"Shima","sequence":"additional","affiliation":[{"name":"Division of Microscopic and Developmental Anatomy, Department of Anatomy Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"issue":"8","key":"e_1_2_11_2_1","first-page":"1249","article-title":"Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu\u2010factor I","volume":"6","author":"Lala DS","year":"1992","journal-title":"Mol Endocrinol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)37129-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00142-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90211-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00071"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69065"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-022-02601-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23226"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.06.005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002040104"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000807)423:4<579::AID-CNE4>3.0.CO;2-#"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20030"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.08.021"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.2.8652"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18206"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2847"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0249-8"},{"issue":"11","key":"e_1_2_11_19_1","article-title":"Rap1 in the VMH regulates glucose homeostasis. 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